Document Detail

Susceptibility to ischemic insult in hypertensive rats: correlation between degree of ischemia and hypertension.
MedLine Citation:
PMID:  3016358     Owner:  NLM     Status:  MEDLINE    
The Wistar rat, with a blood pressure range of 120-160 mmHg, and two strains of spontaneously hypertensive rats (SHR), stroke-prone (SHRSP, range 210-270 mmHg) and stroke-resistant (SHRSR, range 160-240 mmHg), were used to determine the degree of damage after ischemic insult induced by bilateral carotid artery ligation (BLCL). The survival rate and McGraw Stroke Index correlated well with the degree of hypertension. After BLCL, impairment of cerebral blood flow is abrupt and residual flow is near zero in rats with initial blood pressures greater than 200 mmHg. A markedly deteriorated aerobic metabolism, as measured by the concentrations of ATP, c-AMP and lactate, is seen to precipitate in rats with initial blood pressures greater than 180 mmHg and severe edema occurs if the pressure is more than 160 mmHg. The degree of hypertension that produces high vulnerability to stroke and severe damage to the brain after ischemic insult is indicated as beginning at about 180 mmHg.
Y Katayama; S Sugimoto; K Inamura; T Soeda; J Shimizu; S Suzuki; A Nagazumi; A Terashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  50     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  258-64     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphate / metabolism
Body Water / metabolism
Brain / metabolism
Brain Ischemia / physiopathology*
Carotid Arteries
Cerebrovascular Circulation
Cyclic AMP / metabolism
Hypertension / physiopathology*
Lactates / metabolism
Lactic Acid
Rats, Inbred SHR
Rats, Inbred Strains
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid; 56-65-5/Adenosine Triphosphate; 60-92-4/Cyclic AMP

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