Document Detail


Susceptibility to PTSD-Like Behavior Is Mediated by Corticotropin-Releasing Factor Receptor Type 2 Levels in the Bed Nucleus of the Stria Terminalis.
MedLine Citation:
PMID:  22593059     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Posttraumatic stress disorder (PTSD) is a debilitating disease, which affects 8-10% of the population exposed to traumatic events. The factors that make certain individuals susceptible to PTSD and others resilient are currently unknown. Corticotropin-releasing factor receptor type 2 (CRFR2) has been implicated in mediating stress coping mechanisms. Here, we use a physiological PTSD-like animal model and an in-depth battery of tests that reflect the symptomology of PTSD to separate mice into subpopulations of "PTSD-like" and "Resilient" phenotypes. PTSD-like mice are hypervigilant, hyperalert, insomniac, have impaired attention and risk assessment, as well as accompanying attenuated corticosterone levels. Intriguingly, PTSD-like mice show long-term robust upregulation of BNST-CRFR2 mRNA levels, and BNST-CRFR2-specific lentiviral knockdown reduces susceptibility to PTSD-like behavior. Additionally, using a BNST mRNA expression array, PTSD-like mice exhibit a general transcriptional attenuation profile, which was associated with upregulation of the BNST-deacetylation enzyme, HDAC5. We suggest PTSD to be a disease of maladaptive coping.
Authors:
Maya Lebow; Adi Neufeld-Cohen; Yael Kuperman; Michael Tsoory; Shosh Gil; Alon Chen
Related Documents :
18787789 - Inhibition of skin inflammation and atopic dermatitis by topical application of a novel...
17956979 - Sulforaphane mobilizes cellular defenses that protect skin against damage by uv radiation.
3096709 - Sencar mouse skin tumorigenesis model versus other strains and stocks of mice.
8658019 - Tumor necrosis factor-alpha stimulates the production of squamous cell carcinoma antige...
22813799 - Formation of duodenal atresias in fibroblast growth factor receptor 2iiib-/- mouse embr...
10233769 - Inhibition of solar simulator-induced p53 mutations and protection against skin cancer ...
18438879 - Arthritis develops but fails to resolve during inhibition of cyclooxygenase 2 in a muri...
2169729 - Induction and stimulation of 92-kda gelatinase/type iv collagenase production in osteos...
11886449 - Different respiratory control systems are affected in homozygous and heterozygous kreis...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  32     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6906-16     Citation Subset:  IM    
Affiliation:
Departments of Neurobiology and Veterinary Resources, Weizmann Institute of Science, Rehovot 76100, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  PMCA2 via PSD-95 controls calcium signaling by ?7-containing nicotinic acetylcholine receptors on as...
Next Document:  Rewiring of Afferent Fibers in the Somatosensory Thalamus of Mice Caused by Peripheral Sensory Nerve...