| Susceptibility to fraud in systematic reviews: lessons from the Reuben case. | |
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MedLine Citation:
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PMID: 19934873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dr. Scott Reuben allegedly fabricated data. The authors of the current article examined the impact of Reuben reports on conclusions of systematic reviews. METHODS: The authors searched in ISI Web of Knowledge systematic reviews citing Reuben reports. Systematic reviews were grouped into one of three categories: I, only cited but did not include Reuben reports; II, retrieved and considered, but eventually excluded Reuben reports; III, included Reuben reports. For quantitative systematic reviews (i.e., meta-analyses), a relevant difference was defined as a significant result becoming nonsignificant (or vice versa) by excluding Reuben reports. For qualitative systematic reviews, each author decided independently whether noninclusion of Reuben reports would have changed conclusions. RESULTS: Twenty-five systematic reviews (5 category I, 6 category II, 14 category III) cited 27 Reuben reports (published 1994-2007). Most tested analgesics in surgical patients. One of 6 quantitative category III reviews would have reached different conclusions without Reuben reports. In all 6 (30 subgroup analyses involving Reuben reports), exclusion of Reuben reports never made any difference when the number of patients from Reuben reports was less than 30% of all patients included in the analysis. Of 8 qualitative category III reviews, all authors agreed that one would certainly have reached different conclusions without Reuben reports. For another 4, the authors' judgment was not unanimous. CONCLUSIONS: Carefully performed systematic reviews proved robust against the impact of Reuben reports. Quantitative systematic reviews were vulnerable if the fraudulent data were more than 30% of the total. Qualitative systematic reviews seemed at greater risk than quantitative. |
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Authors:
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Emmanuel Marret; Nadia Elia; J??rgen B Dahl; Henry J McQuay; Steen M??iniche; R Andrew Moore; Sebastian Straube; Martin R Tram??r |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anesthesiology Volume: 111 ISSN: 1528-1175 ISO Abbreviation: Anesthesiology Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2009-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 1279-89 Citation Subset: AIM; IM |
Affiliation:
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Division of Anesthesiology, Department of Anesthesiology, Critical Care and Clinical Pharmacology, Geneva University Hospitals, Geneva, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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adverse effects,
therapeutic use Cyclooxygenase 2 Inhibitors / adverse effects, therapeutic use Humans Meta-Analysis as Topic* Pain, Postoperative / drug therapy Randomized Controlled Trials as Topic Review Literature as Topic* Scientific Misconduct* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Cyclooxygenase 2 Inhibitors |
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