| Susceptibility of skin and soft-tissue isolates of Staphylococcus aureus and Streptococcus pyogenes to topical antibiotics: indications of clonal spread of fusidic acid-resistant Staphylococcus aureus. | |
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MedLine Citation:
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PMID: 12693555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Staphylococcus aureus (SA) isolates (n = 255) from outpatients with skin and soft-tissue infections were collected in 3 different areas in Norway. Group A streptococci (GAS, n = 68) were isolated from skin or pharyngotonsillar specimens from outpatients. Minimum inhibitory concentrations (MIC) of bacitracin, fusidic acid and mupirocin were tested using the E-test. Pulsed field gel electrophoresis (PFGE) patterns of fusidic acid-sensitive (FusS) and -resistant (FusR) SA were compared. All GAS isolates showed MIC of bacitracin of < or = 1.0 mg/l, of mupirocin of < or = 0.125 mg/l and of fusidic acid 1.0-4.0 mg/l. All the SA showed MIC of mupirocin < or = 0.5 mg/l and of bacitracin of > or = 2.0 mg/l, 91% with MIC > or = 16 mg/l. FusR was shown by 32.5% of the SA strains with similar prevalence rates in 3 different geographical areas of Norway. One particular PFGE pattern (type 1) was shown by 76% of the FusR SA. SA of type 1 belonged to phage group II and produced exfoliative toxins. Thus, the results demonstrated a high prevalence of FusR among SA causing skin infections and that this was mainly due to dissemination of clonally related FusR SA. |
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Authors:
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Jan Egil Afset; Johan A Maeland |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of infectious diseases Volume: 35 ISSN: 0036-5548 ISO Abbreviation: Scand. J. Infect. Dis. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-04-15 Completed Date: 2003-05-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0215333 Medline TA: Scand J Infect Dis Country: Sweden |
Other Details:
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Languages: eng Pagination: 84-9 Citation Subset: IM |
Affiliation:
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Department of Microbiology, School of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. jan.afset@rit.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adolescent Adult Anti-Bacterial Agents / pharmacology*, therapeutic use Bacitracin / pharmacology Child Drug Resistance, Bacterial Electrophoresis, Gel, Pulsed-Field Female Fusidic Acid / pharmacology* Genes, Bacterial Humans Male Microbial Sensitivity Tests Middle Aged Mupirocin / pharmacology Probability Sensitivity and Specificity Skin Diseases, Bacterial / drug therapy, microbiology Soft Tissue Infections / drug therapy, microbiology Staphylococcal Infections / drug therapy Staphylococcus aureus / drug effects, genetics* Streptococcal Infections / drug therapy Streptococcus pyogenes / drug effects, genetics* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 12650-69-0/Mupirocin; 1405-87-4/Bacitracin; 6990-06-3/Fusidic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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