Document Detail

Susceptibility of sheep to European bat lyssavirus type-1 and -2 infection: a clinical pathogenesis study.
MedLine Citation:
PMID:  17706900     Owner:  NLM     Status:  MEDLINE    
European bat lyssaviruses (EBLVs) have been known to cross the species barrier from their native bat host to other terrestrial mammals. In this study, we have confirmed EBLV-1 and EBLV-2 susceptibility in sheep (Ovis ammon) following intracranial and peripheral (intramuscular) inoculation. Notably, mild clinical disease was observed in those exposed to virus via the intramuscular route. Following the intramuscular challenge, 75% of the animals infected with EBLV-1 and 100% of those that were challenged with EBLV-2 developed clinical signs of rabies and then recovered during the 94-day observation period. Disease pathogenesis also varied substantially between the two viruses. Infection with EBLV-1 resulted in peracute clinical signs, which are suggestive of motor neuron involvement. Antibody induction was observed and substantial inflammatrory infiltrate in the brain. In contrast, more antigen was detected in the EBLV-2-infected sheep brains but less inflammatory infiltrate and no virus neutralising antibody was evident. The latter involved a more protracted disease that was behaviour orientated. A high infectious dose was required to establish EBLV infection under experimental conditions (> or =5.0 logs/ml) but the infectious dose in field cases remains unknown. These data confirm that sheep are susceptible to infection with EBLV but that there is variability in pathogenesis including neuroinvasiveness that varies with the route of infection. This study suggests that inter-species animal-to-animal transmission of a bat variant of rabies virus to a terrestrial mammal host may be limited, and may not always result in fatal encephalitis.
Sharon M Brookes; Robert Klopfleisch; Thomas Müller; Derek M Healy; Jens P Teifke; Elke Lange; Janette Kliemt; Nick Johnson; Linda Johnson; Volker Kaden; Adriaan Vos; Anthony R Fooks
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-15
Journal Detail:
Title:  Veterinary microbiology     Volume:  125     ISSN:  0378-1135     ISO Abbreviation:  Vet. Microbiol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-10-23     Completed Date:  2008-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705469     Medline TA:  Vet Microbiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  210-23     Citation Subset:  IM    
Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency (VLA, Weybridge), WHO Collaborating Centre for the Characterisation of Rabies and Rabies-related Viruses, New Haw, Addlestone, UK.
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MeSH Terms
Antibodies, Viral / blood
Antigens, Viral / analysis
Brain Diseases / pathology,  veterinary*,  virology
Fluorescent Antibody Technique, Direct / veterinary
Immunohistochemistry / veterinary
Lyssavirus / genetics,  growth & development*
Neutralization Tests / veterinary
RNA, Viral / chemistry,  genetics
Random Allocation
Reverse Transcriptase Polymerase Chain Reaction / veterinary
Rhabdoviridae Infections / pathology,  veterinary*,  virology
Sheep Diseases / pathology,  virology*
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 0/RNA, Viral

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