Document Detail

Susceptibility of pregnant women to toxoplasma infection--potential benefits for newborn screening.
MedLine Citation:
PMID:  18807815     Owner:  NLM     Status:  MEDLINE    
Congenital toxoplasmosis (CT) arises as a result of new acquisition of Toxoplasma infection by a susceptible woman during pregnancy. Early detection of CT through neonatal screening programmes could optimize management and improve infant outcome. This study sought to estimate the prevalence of Toxoplasma susceptibility in pregnant women. As detection of Toxoplasma antibodies in neonatal blood reflects maternal exposure history, maternal antibody seroprevalence was determined using anonymized residual blood from newborn screening cards. A total of 20,252 cards were tested in 1 year. 4,991 (24.6%) cards tested positive for Toxoplasma antibody. Results were stratified by county. Toxoplasma antibody seroprevalence rates of 25% indicated that Toxoplasma infection is common in Ireland and that up to 75% of women remain susceptible to primary infection during pregnancy. This study aimed to a) determine the seroprevalence of Toxoplasma antibody in pregnant women, and hence b) estimate the risk for acquisition of primary toxoplasmosis in pregnancy in order to support an application to fund a pilot newborn screening programme.
W Ferguson; P D Mayne; B Lennon; K Butler; M Cafferkey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Irish medical journal     Volume:  101     ISSN:  0332-3102     ISO Abbreviation:  Ir Med J     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-09-22     Completed Date:  2008-10-31     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0430275     Medline TA:  Ir Med J     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  220-1     Citation Subset:  IM    
The Rotunda Hospital, Parnell Street, Dublin.
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MeSH Terms
Disease Susceptibility*
Infant, Newborn
Ireland / epidemiology
Neonatal Screening*
Risk Factors
Seroepidemiologic Studies
Toxoplasmosis, Congenital / blood,  diagnosis*,  epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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