| Susceptibility of a grass-pollen oral immunotherapy extract to the saliva and gastric fluid digestive process. | |
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MedLine Citation:
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PMID: 8059676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The oral and sublingual immunotherapy is still a controversial therapeutic procedure. One of the problems is knowing how much allergenic activity could the extracts loss due to the digestive process into the mouth and stomach. Using a grass-pollen oral and sublingual immunotherapy extract, we studied its degradation until reaching the small intestine. For this purpose we employed an in vitro model using the RAST-inhibition assay. We observed a 3.8 fold loss of allergenic activity after a 30 sec-incubation with saliva; a subsequent 5 min-incubation with gastric fluid got a final loss of allergenic activity of 10.3 fold. The incubation times were those expected occurring during the ingestion of the extract. It was surprising that after the enzymatic and acid actions of the gastric fluid, an important degree of allergenic activity still remained in the extract. This issue should be taken into account when considering the dose to be administered in oral and sublingual immunotherapy. |
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Authors:
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J M Igea; M Cuevas; M Lázaro; S Quirce; J Cuesta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Allergologia et immunopathologia Volume: 22 ISSN: 0301-0546 ISO Abbreviation: Allergol Immunopathol (Madr) Publication Date: 1994 Mar-Apr |
Date Detail:
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Created Date: 1994-09-13 Completed Date: 1994-09-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370073 Medline TA: Allergol Immunopathol (Madr) Country: SPAIN |
Other Details:
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Languages: eng Pagination: 55-9 Citation Subset: IM |
Affiliation:
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Clínica Alergoasma, Salamanca, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Administration, Sublingual Adult Allergens / administration & dosage, immunology, metabolism* Desensitization, Immunologic* Gastric Juice / metabolism* Humans Plant Extracts / administration & dosage, immunology, metabolism*, pharmacokinetics Plant Proteins / immunology, metabolism Poaceae Pollen / immunology* Protein Denaturation Radioallergosorbent Test Saliva / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Plant Extracts; 0/Plant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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