| Susceptibility of aging human bone to mixed-mode fracture increases bone fragility. | |
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MedLine Citation:
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PMID: 16182625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since bone-mass-based measurements have demonstrated limited success in predicting age-related increase in fracture incidence, recent emphasis has been placed on quantification of bone quality. Specifically, material parameters such as strength, stiffness, and toughness have been quantified to characterize bone quality through mechanical testing. This study is the first one to report multiaxial failure characteristics of bone (quality) by conducting fatigue tests on human cortical bone specimens under physiologically relevant loading involving simultaneous application of axial and torsional loading to produce previously reported in vivo shear/normal stress ratios. Our results show that, compared to uniaxial tests, multiaxial fatigue tests show up to a 20-fold reduction in the fatigue life of human cortical bone. More significantly, the susceptibility of mixed-mode failure increases bone fragility in aging human bone. Furthermore, since the magnitude of mixed-mode loading varies with physiological activities, results of this study also suggest that a reduction in the activities involving significant mixed-mode loading may lower the overall fracture incidence among older individuals. |
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Authors:
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W T George; D Vashishth |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-22 |
Journal Detail:
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Title: Bone Volume: 38 ISSN: 8756-3282 ISO Abbreviation: Bone Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-02 Completed Date: 2006-05-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8504048 Medline TA: Bone Country: United States |
Other Details:
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Languages: eng Pagination: 105-11 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Room 7046, Jonnson Engineering Center, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12182, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / physiology* Disease Susceptibility Fractures, Stress / etiology*, physiopathology Humans Male Microscopy, Electron, Scanning Middle Aged Stress, Mechanical Tensile Strength / physiology Tibia / injuries, physiology* Tibial Fractures / physiopathology* Torsion Abnormality / physiopathology Weight-Bearing / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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