Document Detail


Susceptibility of Trypanosoma evansi to propolis extract in vitro and in experimentally infected rats.
MedLine Citation:
PMID:  22405907     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Current therapy of Trypanosoma evansi infections is not effective for the vast majority of animals with relapsing parasitemia and clinical signs. Recently, attention is being focused on the antiparasitic activity of propolis. This study evaluated the susceptibility of T. evansi to propolis extract in vitro and in vivo. A dose-dependent trypanocidal activity of propolis extract was observed in vitro. All trypomastigotes were killed 1h after incubation with 10μgmL(-1) of the extract. In vivo, the concentrations of 100, 200, 300 and 400mgkg(-1) administered orally for 10 consecutive days showed no curative effect, and the rats died from the disease. However, rats treated with the two highest concentrations of propolis extract showed higher longevity than the other groups. Based on these data, we concluded that T. evansi is susceptible to propolis in vitro. Despite the lack of curative efficacy observed in vivo at the concentrations tested, the propolis extract can prolong life in rats infected with the protozoan.
Authors:
Lucas T Gressler; Aleksandro S Da Silva; Gustavo Machado; Luciana Dalla Rosa; Fellipe Dorneles; Letícia T Gressler; Mauricio S Oliveira; Régis A Zanette; Agueda C P de Vargas; Silvia G Monteiro
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-9
Journal Detail:
Title:  Research in veterinary science     Volume:  -     ISSN:  1532-2661     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Brazil.
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