Document Detail

Susceptibility loci and chromosomal abnormalities in radiation induced hematopoietic neoplasms in mice.
MedLine Citation:
PMID:  21343679     Owner:  NLM     Status:  MEDLINE    
Genetics of susceptibility to radiation-induced hematopoietic neoplasms and somatic chromosomal aberrations were analyzed in 305 backcross (CcS-17xCcS-2)xCcS-2 mice of two CcS/Dem recombinant congenic strains. Irradiated CcS-2 mice were previously shown to exhibit high frequency of myeloid neoplasms whereas irradiated CcS-17 mice were susceptible to T-cell lymphomas. Mice were exposed to four whole-body irradiation doses of 1.7 Gy at one week intervals, which resulted in 139 hematopoietic neoplasms. The hematopoietic neoplasms were classified according to the Bethesda proposals for classification of lymphoid and nonlymphoid hematopoietic neoplasms in mice. Genotyping of mice with 24 microsatellite markers and subsequent statistical analysis indicated linkage of the radiation induced T-lymphomas to two loci on chromosome 10 (D10Mit134) and chromosome 12 (D12Mit52). T-lymphoma susceptibility appeared to be linked to D10Mit134 in a sex dependent way. In contrast, the myeloid-granulocytic leukemias susceptibility is linked to combined effects of chromosome 5 (D5Mit179) and 16 (D16Mit34). Cytogenetic analysis was performed according to the standard G-bands procedure and confirmed using FISH method. We found non-random numerical and structural chromosomal changes in lymphoid neoplasms. Cytogenetic analysis indicated chromosomal aberrations presumably associated with lymphomagenesis, no specific cancer-related rearrangements were observed.
Joanna Piskorowska; Marta Gajewska; Hanna Szymańska; Elzbieta Krysiak; Lei Quan; Beata Grygalewicz; Henryk M Skurzak; Alina Czarnomska; Barbara Pienkowska-Grela; Peter Demant
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Publication Detail:
Type:  Journal Article     Date:  2011-02-19
Journal Detail:
Title:  Journal of radiation research     Volume:  52     ISSN:  1349-9157     ISO Abbreviation:  J. Radiat. Res.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-07-05     Revised Date:  2012-03-28    
Medline Journal Info:
Nlm Unique ID:  0376611     Medline TA:  J Radiat Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  147-58     Citation Subset:  IM    
Department of Genetics and Laboratory Animal Breeding, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
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MeSH Terms
Chromosome Aberrations*
Chromosome Mapping
Chromosomes / radiation effects*
Crosses, Genetic
Genetic Predisposition to Disease*
Hematologic Neoplasms / etiology,  genetics*
In Situ Hybridization, Fluorescence
Mice, Inbred BALB C
Microsatellite Repeats
Models, Genetic
Neoplasms, Radiation-Induced / etiology,  genetics*
Quantitative Trait Loci

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