| Susac's syndrome: beneficial effects of corticosteroid therapy in a Japanese case. | |
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MedLine Citation:
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PMID: 11300147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Susac's syndrome is a rare disorder characterized by the triad of microangiopathy of the brain and retina with hearing loss. More than 50 affected individuals have been reported worldwide, all Caucasians. We herein identify the first Japanese patient with Susac's syndrome. A 36-year-old man developed recurrent subacute encephalopathy, bi- a lateral sensorineural hearing loss, and retinal arteriolar occlusions, caused by microangiopathy from a year previously. T2-weighted MRI showed multiple high-signal lesions ti predominantly in the periventricular white matter. During the exacerbated phase both high-dose intravenous methyl-prednisolone and oral prednisone therapy produced beneficial effects. He showed definite remission within 2 years from the disease onset. |
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Authors:
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K Tashima; E Uyama; Y Hashimoto; T Yonehara; M Uchino |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 40 ISSN: 0918-2918 ISO Abbreviation: Intern. Med. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-04-12 Completed Date: 2001-07-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 135-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, Kumamoto University School of Medicine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents / therapeutic use* Asian Continental Ancestry Group Asthma / complications Ataxia / etiology Brain / pathology Cognition Disorders / etiology Confusion / etiology Diagnosis, Differential Diltiazem / therapeutic use Drug Therapy, Combination Hearing Loss, Bilateral / diagnosis, drug therapy* Hearing Loss, Sensorineural / diagnosis, drug therapy* Humans Magnetic Resonance Imaging Male Methylprednisolone / therapeutic use* Multiple Sclerosis / diagnosis Papilledema / diagnosis, drug therapy* Prednisone / therapeutic use* Reflex, Abnormal Retinal Artery / pathology Retinal Artery Occlusion / diagnosis, drug therapy* Skin Diseases, Vascular / etiology Syndrome Ticlopidine / therapeutic use Vasculitis, Central Nervous System / diagnosis, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 42399-41-7/Diltiazem; 53-03-2/Prednisone; 55142-85-3/Ticlopidine; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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