Document Detail

Susac Syndrome and Pregnancy: Disease Management.
MedLine Citation:
PMID:  21325959     Owner:  NLM     Status:  Publisher    
Susac syndrome (SS) consists of a triad of vision loss, hearing loss, and encephalopathy due to autoimmune-mediated vascular endothelial injury. Herein we describe a 25-year-old previously healthy woman who presented at 20 weeks' gestation with symptoms of confusion, difficulty walking, and vision and hearing loss. She had branch-retinal artery occlusions on funduscopic examination, and sensorineural hearing loss. Additionally, non-contrast enhanced brain magnetic resonance imaging showed multiple white matter and callosal lesions consistent with ischemia. She was treated initially with aspirin, corticosteroids, and intravenous immunoglobulin with early improvement, although recurrent disease was treated with cyclophosphamide and rituximab after induction of premature delivery (at 35 weeks' gestation) to spare the fetus possible toxicity. We additionally discuss a general overview of SS, what is known about pregnancy and this disease, and issues regarding diagnostic and treatment approaches for SS during pregnancy.
Kevin D Deane; Kim N Tyler; David W Johnson; Jody L Tanabe; Bjorn E Oskarrson; Ernest E Nitka; Elizabeth Brass; Jill K Davies; Christopher C Striebich
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-10
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  -     ISSN:  1536-7355     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the *Division of Rheumatology, University of Colorado School of Medicine, and Departments of †Ophthalmology; ‡Radiology, University of Colorado, Denver, CO; §Department of Neurology, University of California, Davis, CA; ∥Neurospecialty Associates, Lakewood; and ¶Department of Obstetrics and Gynecology and #Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado, Denver, CO.
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