Document Detail

Survivor function estimators under group sequential monitoring based on the logrank statistic.
MedLine Citation:
PMID:  12735495     Owner:  NLM     Status:  MEDLINE    
In this paper we investigate a group sequential analysis of censored survival data with staggered entry, in which the trial is monitored using the logrank test while comparisons of treatment and control Kaplan-Meier curves at various time points are performed at the end of the trial. We concentrate on two-sample tests under local alternatives. We describe the relationship of the asymptotic bias of Kaplan-Meier curves between the two groups. We show that even if the asymptotic bias of the Kaplan-Meier curve is negligible relative to the true survival, this is not the case for the difference between the curves of the two arms of the trial. A corrected estimator for the difference between the survival curves is presented and by simulations we show that the corrected estimator reduced the bias dramatically and has a smaller variance. The methods of estimation are applied to the Beta-Blocker Heart Attack Trial (1982), a well-known group sequential trial.
Malka Gorfine
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Lifetime data analysis     Volume:  9     ISSN:  1380-7870     ISO Abbreviation:  Lifetime Data Anal     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-08     Completed Date:  2003-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9516348     Medline TA:  Lifetime Data Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-93     Citation Subset:  IM    
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N. MP1002, PO Box 19024, Seattle, WA 98109-1024, USA.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Bias (Epidemiology)
Clinical Trials as Topic / statistics & numerical data
Computer Simulation
Myocardial Infarction / drug therapy,  mortality,  prevention & control
Proportional Hazards Models*
Survival Analysis*
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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