| Survivin: a target from brain cancer to neurodegenerative disease. | |
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MedLine Citation:
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PMID: 20925597 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Apoptosis is an important contributing factor during neuronal death in a variety of neurodegenerative disorders, including multiple sclerosis, Parkinson's disease and sciatic nerve injury. Whereas several clinical and preclinical studies have focused on the neuroprotective effects of caspase inhibitors, their clinical benefits are still unclear. Here, we discuss novel alternative strategies to protect neuronal cells from apoptotic death using members of the inhibitors of apoptosis (IAP) family. We specifically review the different roles of survivin, which is an important member of the IAP family that serves a dual role in the inhibition of apoptosis as well as a vital role in mitosis and cell division. Due to the various roles of survivin during cell division and apoptosis, targeting this protein illustrates a new therapeutic window for the treatment of neurodegenerative diseases. |
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Authors:
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Sara Baratchi; Rupinder K Kanwar; Jagat R Kanwar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-07 |
Journal Detail:
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Title: Critical reviews in biochemistry and molecular biology Volume: 45 ISSN: 1549-7798 ISO Abbreviation: Crit. Rev. Biochem. Mol. Biol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8903774 Medline TA: Crit Rev Biochem Mol Biol Country: England |
Other Details:
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Languages: eng Pagination: 535-54 Citation Subset: IM |
Affiliation:
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Centre for Biotechnology and Interdisciplinary Biosciences (BioDeakin), Institute for Technology Research and Innovation (ITRI), Deakin University, Waurn Ponds, Victoria, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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