Document Detail

Survivin reduces activation-induced T cell death in G1 phase.
MedLine Citation:
PMID:  14651254     Owner:  NLM     Status:  MEDLINE    
A process termed activation-induced cell death (AICD) is responsible for peripheral T cell tolerance after negative selection of self-reactive T cells, and deletion of hyperactivated T cells following the immune response. Cells in G1 phase of the cell cycle are most susceptible to AICD. We have investigated the relationship between the induction of AICD by phorbol 12-myristate 13-acetate plus ionomycin during the cell cycle and the expression of survivin, an inhibitor of the apoptosis protein (LAP) family. AICD was highly induced in cells of the human T cell line Jurkat E6.1 arrested in G1 phase, whereas survivin was hardly expressed in G1 and instead it was highly expressed in G2/M. Moreover, transient over-expression of survivin in G1 partially blocked the induction of AICD. These results suggest that survivin inhibits the induction of AICD, especially in G1 phase.
Hee-Kyoung Shon; Kyung-Joo Cho; An-Sik Chung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecules and cells     Volume:  16     ISSN:  1016-8478     ISO Abbreviation:  Mol. Cells     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-11-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610936     Medline TA:  Mol Cells     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  IM    
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
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MeSH Terms
Carcinogens / pharmacology
Caspase 3
Caspases / metabolism
Cell Death / immunology,  physiology*
G1 Phase / physiology*
Ionomycin / pharmacology
Jurkat Cells
Microtubule-Associated Proteins / metabolism*
Neoplasm Proteins
T-Lymphocytes / drug effects,  immunology*,  metabolism
Tetradecanoylphorbol Acetate / pharmacology
Reg. No./Substance:
0/BIRC5 protein, human; 0/Carcinogens; 0/Microtubule-Associated Proteins; 0/Neoplasm Proteins; 16561-29-8/Tetradecanoylphorbol Acetate; 56092-81-0/Ionomycin; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases

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