| Survivin mRNA antagonists using locked nucleic acid, potential for molecular cancer therapy. | |
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MedLine Citation:
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PMID: 18066798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have investigated the effects of different locked nucleic acid modified antisense mRNA antagonists against Survivin in a prostate cancer model. These mRNA antagonists were found to be potent inhibitors of Survivin expression at low nanomolar concentrations. Additionally there was a pronounced synergistic effect when combining the mRNA antagonists against Survivin with the chemotherapeutic Taxol. This effect was demonstrated at concentrations of antagonists far lower than any previously demonstrated, indicating the high potential of locked nucleic acid for therapeutic use. Further characterisations in vivo are ongoing. |
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Authors:
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Niels Fisker; Majken Westergaard; Henrik Frydenlund Hansen; Jens Bo Hansen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 26 ISSN: 1525-7770 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-10 Completed Date: 2008-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: United States |
Other Details:
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Languages: eng Pagination: 1427-30 Citation Subset: IM |
Affiliation:
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Santaris Pharma A/S, Boege Allé 3, DK-2970 Hoersholm, Denmark. NFN@santaris.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology*,
therapeutic use Cell Line, Tumor Humans Male Microtubule-Associated Proteins / antagonists & inhibitors* Neoplasm Proteins / antagonists & inhibitors* Oligonucleotides / chemistry* Prostatic Neoplasms / drug therapy* RNA, Antisense / chemistry, pharmacology*, therapeutic use RNA, Messenger / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/BIRC5 protein, human; 0/Microtubule-Associated Proteins; 0/Neoplasm Proteins; 0/Oligonucleotides; 0/RNA, Antisense; 0/RNA, Messenger; 0/locked nucleic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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