|Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation.|
|PMID: 10918579 Owner: NLM Status: MEDLINE|
|Survivin is observed uniquely in tumor cells and developmental cells, which undergo either inappropriate or programmed cell growth. In the current study, we investigated the influence of Survivin on cell cycle. Overexpression of Survivin resulted in accelerated S phase shift, resistance to G1 arrest, and activated Cdk2/Cyclin E complex leading Rb phosphorylation. In addition, nuclear translocation of Survivin followed by an interaction with Cdk4 was detected. Interestingly, Survivin nuclear translocation coincided with S phase shift, and prevention of nuclear transport suppressed Survivin nuclear translocation and S phase shift. Further, we also observed that Survivin competitively interacted with the Cdk4/p16(INK4a) complex in a cell free system and in vivo. These results suggest that Survivin initiates the cell cycle entry as a result of nuclear translocation followed by an interaction with Cdk4.|
|A Suzuki; M Hayashida; T Ito; H Kawano; T Nakano; M Miura; K Akahane; K Shiraki|
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|Type: Journal Article; Research Support, Non-U.S. Gov't|
|Title: Oncogene Volume: 19 ISSN: 0950-9232 ISO Abbreviation: Oncogene Publication Date: 2000 Jul|
|Created Date: 2000-08-16 Completed Date: 2000-08-16 Revised Date: 2012-06-25|
Medline Journal Info:
|Nlm Unique ID: 8711562 Medline TA: Oncogene Country: ENGLAND|
|Languages: eng Pagination: 3225-34 Citation Subset: IM|
|Basic Technology Research Laboratory, Daiichi Pharamceutical Co. Ltd., Tokyo R&D Center, Japan.|
|APA/MLA Format Download EndNote Download BibTex|
Amino Acid Sequence
Carrier Proteins / metabolism*
Cell Nucleus / metabolism
Cyclin E / metabolism*
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases / metabolism*
Inhibitor of Apoptosis Proteins
Molecular Sequence Data
Protein-Serine-Threonine Kinases / metabolism*
Proteins / genetics, immunology, metabolism*
Recombinant Fusion Proteins / genetics, immunology, metabolism
Retinoblastoma Protein / metabolism
Tumor Cells, Cultured
|0/BIRC5 protein, human; 0/Carrier Proteins; 0/Cyclin E; 0/Cyclin-Dependent Kinase Inhibitor p16; 0/Inhibitor of Apoptosis Proteins; 0/Microtubule-Associated Proteins; 0/Neoplasm Proteins; 0/Proteins; 0/Proto-Oncogene Proteins; 0/Recombinant Fusion Proteins; 0/Retinoblastoma Protein; EC 220.127.116.11/Protein-Serine-Threonine Kinases; EC 18.104.22.168/CDC2-CDC28 Kinases; EC 22.214.171.124/CDK2 protein, human; EC 126.96.36.199/CDK4 protein, human; EC 188.8.131.52/Cyclin-Dependent Kinase 2; EC 184.108.40.206/Cyclin-Dependent Kinase 4; EC 220.127.116.11/Cyclin-Dependent Kinases|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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