Document Detail

Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation.
MedLine Citation:
PMID:  10918579     Owner:  NLM     Status:  MEDLINE    
Survivin is observed uniquely in tumor cells and developmental cells, which undergo either inappropriate or programmed cell growth. In the current study, we investigated the influence of Survivin on cell cycle. Overexpression of Survivin resulted in accelerated S phase shift, resistance to G1 arrest, and activated Cdk2/Cyclin E complex leading Rb phosphorylation. In addition, nuclear translocation of Survivin followed by an interaction with Cdk4 was detected. Interestingly, Survivin nuclear translocation coincided with S phase shift, and prevention of nuclear transport suppressed Survivin nuclear translocation and S phase shift. Further, we also observed that Survivin competitively interacted with the Cdk4/p16(INK4a) complex in a cell free system and in vivo. These results suggest that Survivin initiates the cell cycle entry as a result of nuclear translocation followed by an interaction with Cdk4.
A Suzuki; M Hayashida; T Ito; H Kawano; T Nakano; M Miura; K Akahane; K Shiraki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncogene     Volume:  19     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-16     Completed Date:  2000-08-16     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3225-34     Citation Subset:  IM    
Basic Technology Research Laboratory, Daiichi Pharamceutical Co. Ltd., Tokyo R&D Center, Japan.
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MeSH Terms
Amino Acid Sequence
Binding, Competitive
Biological Transport
CDC2-CDC28 Kinases*
Carrier Proteins / metabolism*
Cell Cycle
Cell Nucleus / metabolism
Cyclin E / metabolism*
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinases / metabolism*
Enzyme Activation
Inhibitor of Apoptosis Proteins
Microtubule-Associated Proteins*
Molecular Sequence Data
Neoplasm Proteins
Neutralization Tests
Protein-Serine-Threonine Kinases / metabolism*
Proteins / genetics,  immunology,  metabolism*
Proto-Oncogene Proteins*
Recombinant Fusion Proteins / genetics,  immunology,  metabolism
Retinoblastoma Protein / metabolism
Tumor Cells, Cultured
Reg. No./Substance:
0/BIRC5 protein, human; 0/Carrier Proteins; 0/Cyclin E; 0/Cyclin-Dependent Kinase Inhibitor p16; 0/Inhibitor of Apoptosis Proteins; 0/Microtubule-Associated Proteins; 0/Neoplasm Proteins; 0/Proteins; 0/Proto-Oncogene Proteins; 0/Recombinant Fusion Proteins; 0/Retinoblastoma Protein; EC Kinases; EC Kinases; EC protein, human; EC protein, human; EC Kinase 2; EC Kinase 4; EC Kinases

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