Document Detail


Survival and reintervention after neonatal repair of truncus arteriosus with valved conduit.
MedLine Citation:
PMID:  18706827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Neonatal primary repair has progressively become the treatment of choice for truncus arteriosus with encouraging survival. However, use of valved conduits to reconstruct the right ventricular outflow tract (RVOT) inevitably induces reintervention. This study estimates survival and rate of catheter-interventional and surgical reinterventions. METHODS: Thirty-five consecutive neonates who underwent truncus repair with 27 homografts and 8 Contegras from 1987 to 2007 were studied. Interrupted aortic arch (IAA) was associated in nine patients. Actuarial survival and freedom from reintervention were evaluated according to Kaplan-Meier method. RESULTS: Five patients died early after repair. Two died late and one death was related to reintervention. Survival was 91.9%+/-5.4% from postoperative month 2 onwards when IAA was not associated and 41.7%+/-17.3% from month 4 in IAA presence. During a median follow-up of 68 months (range 1-180 months), 42 reinterventions (of which 17 reoperations) were performed in 21 patients. Rate of reintervention was 2.6 per early survivor per 10 years. RVOT obstruction constituted the main indication: branch pulmonary arteries often being involved (n=25). Uncommon indication was subaortic stenosis (n=3), aortic arch obstruction (n=2) and truncal valve regurgitation (n=2). At year 10, freedom from first, second and third reintervention was 17.9 %+/-8.1%, 46.1%+/-10.6% and 81.9%+/-9.5%, respectively. Sixteen first conduits were explanted. Freedom from first conduit replacement was 87.5%+/-6.8%, 64.1%+/-10.2% and 39.5%+/-10.7% at year 1, 3 and 5, respectively. Homografts enjoyed higher durability than Contegras. CONCLUSION: Neonatal repair of truncus arteriosus results in high survival, the only risk being IAA association. The rate of reintervention is heavily influenced by stenosis of branch pulmonary arteries.
Authors:
Nicodème Sinzobahamvya; Margaretha Boscheinen; Hedwig C Blaschczok; Rolf Kallenberg; Joachim Photiadis; Christoph Haun; Viktor Hraska; Boulos Asfour
Related Documents :
21856817 - Cinaciguat, a soluble guanylate cyclase activator, augments cgmp after oxidative stress...
9651847 - Histopathologic comparison of a pulmonary autograft and pulmonary homograft in a patien...
12000167 - Bovine jugular vein as right ventricle-to-pulmonary artery valved conduit.
18398217 - Proposal of goodfellowiella gen. nov. to replace the illegitimate genus name goodfellow...
25469067 - Clinical characteristics and survival of korean idiopathic pulmonary arterial hypertens...
12426997 - Origins of the dorsal metatarsal arteries in humans.
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2008-08-15
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  34     ISSN:  1873-734X     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-17     Completed Date:  2009-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  732-7     Citation Subset:  IM    
Affiliation:
Department of Pediatric Thoracic and Cardiovascular Surgery, Congenital Cardiac Center (Deutsches Kinderherzzentrum), Sankt Augustin, Germany. n.sinzobahamvya@asklepios.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age Factors
Aortic Valve / transplantation
Epidemiologic Methods
Female
Humans
Infant, Newborn
Jugular Veins / transplantation
Male
Pulmonary Valve / transplantation
Reoperation
Treatment Outcome
Truncus Arteriosus, Persistent / surgery*
Ventricular Outflow Obstruction / surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Analysis of bedside entertainment services' effect on post cardiac surgery physical activity: a pros...
Next Document:  Characterization of hemicyanine Langmuir-Blodgett films by picosecond time-resolved fluorescence.