| Survival rate of human oocytes and pregnancy outcome after vitrification using slush nitrogen in assisted reproductive technologies. | |
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MedLine Citation:
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PMID: 17350007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report the survival rate of oocytes and the rate of successful pregnancies obtained from super-rapid cooling of oocytes using slush nitrogen (SN(2)). DESIGN: Prospective clinical research. SETTING: A university-affiliated hospital. PATIENT(S): Twenty-eight infertile women who underwent 30 cycles of IVF-ET using previously vitrified oocytes. INTERVENTION(S): Oocytes were vitrified by super-rapid cooling using SN(2). MAIN OUTCOME MEASURE(S): Morphological normality of thawed oocytes and clinical outcome. RESULT(S): In 30 cycles of ovarian stimulation for IVF, 364 surplus oocytes from 28 patients were vitrified using SN(2). Three hundred two (85.1% +/- 2.9%) of the oocytes survived after warming. Fertilization and cleavage rates were 77.4% +/- 3.5% (168/218) and 94.3% +/- 2.1% (158/168), respectively. Thirteen pregnancies (43.3%) resulted from 30 uterine transfers of 120 embryos with an implantation rate of 14.2% (17/120). There were no differences between the pregnancy rate after vitrification/warming and that obtained from routine noncryopreserved oocytes. CONCLUSION(S): The present report suggests that super-rapid cooling may improve the clinical efficacy of human oocyte vitrification and may be a valuable tool for human assisted reproductive technologies. |
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Authors:
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Tae Ki Yoon; Dong Ryul Lee; Soo Kyung Cha; Hyung Min Chung; Woo Sik Lee; Kwang Yul Cha |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-09 |
Journal Detail:
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Title: Fertility and sterility Volume: 88 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-08 Completed Date: 2007-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 952-6 Citation Subset: IM |
Affiliation:
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Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University, College of Medicine, Seoul, Korea. tkyoon@cha.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cryopreservation / methods* Embryo Transfer Female Humans Nitrogen Oocytes* Pregnancy Pregnancy Outcome* Reproductive Techniques, Assisted* |
| Chemical | |
Reg. No./Substance:
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7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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