Document Detail

Survival and predictive factors of mortality after 30 days in patients treated with percutaneous implantation of the CoreValve aortic prosthesis.
MedLine Citation:
PMID:  22305849     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Few data exist on the clinical impact of transcatheter aortic valve implantation (TAVI) in patients with symptomatic aortic stenosis and a high surgical risk. The aim of this study was to determine the survival and the factors predicting mortality after 30 days post-TAVI with the CoreValve prosthesis (Medtronic, Minneapolis, MN).
METHODS: From April 2008 to October 2010, the CoreValve prosthesis (Medtronic) was implanted in 133 consecutive high-risk surgical patients with symptomatic severe aortic stenosis.
RESULTS: The mean age was 79.5 ± 6.7 years. The logistic European System for Cardiac Operative Risk Evaluation was 21.5% ± 14%. The implantation success rate was 97.7%. In-hospital mortality was 4.5%, and the combined end point of death, vascular complications, myocardial infarction, or stroke had a rate of 9%. Survival at 12 and 24 months was 84.5% and 79%, respectively, after a mean follow-up of 11.3 ± 8 months. The New York Heart Association functional class improved from 3.3 ± 0.5 to 1.18 ± 0.4 and remained stable at 1 year. A high Charlson index (hazard ratio [HR] 1.44, 95% CI 1.09-1.89, P < .01) and a worse Karnofsky score before the procedure (HR 0.95, 95% CI 0.92-0.99, P = .021) were predictors of mortality after 30 days.
CONCLUSIONS: Transcatheter aortic valve implantation with the CoreValve prosthesis for patients with aortic stenosis and a high surgical risk is a safe, efficient option resulting in a medium-term clinical improvement. Survival during follow-up depends on the associated comorbidities. Early mortality beyond 30 days is predicted by preoperative comorbidity scores and the functional status of the patient.
Antonio J Muñoz-García; José M Hernández-García; Manuel F Jiménez-Navarro; Juan H Alonso-Briales; Antonio J Domínguez-Franco; Isabel Rodríguez-Bailón; María J Molina-Mora; Paula Hernández-Rodríguez; Miguel Such-Martínez; Eduardo de Teresa-Galván
Related Documents :
23985639 - The mushroom-shaped anterolateral thigh perforator flap for subtotal tongue reconstruct...
24269069 - A new method for defining balance: promising short-term clinical outcomes of sensor-gui...
7035049 - Treatment of group a streptococcal pharyngitis in children. results of a prospective, r...
23146879 - Prognostic value of electrographic postanoxic status epilepticus in comatose cardiac-ar...
22661109 - Simultaneous aortic valve replacement in left ventricular assist device recipients: sin...
23102529 - Configuration of the circle of willis is associated with less symptomatic intracerebral...
21480979 - The use of high-dose melatonin in liver resection is safe: first clinical experience.
22371809 - Effect of ligamenta flava hypertrophy on lumbar disc herniation with contralateral symp...
22633709 - Paroxysmal atrial fibrillation after hyperbaric oxygen therapy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  163     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  288-94     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Department of Cardiology, Virgen de la Victoria Clinical University Hospital, Málaga, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cardiopulmonary exercise function among patients undergoing transcatheter pulmonary valve implantati...
Next Document:  Aggregating traditional cardiovascular disease risk factors to assess the cardiometabolic health of ...