Document Detail

Survival of peritoneal malignant mesothelioma in Italy: a population-based study.
MedLine Citation:
PMID:  18792099     Owner:  NLM     Status:  MEDLINE    
In some population-based studies, a shorter median survival was observed in peritoneal as compared with pleural, malignant mesothelioma, but in others, longer median survival times or higher proportions of long-term survivors were reported. Statistical instability could have caused these differences. We analyzed survival in peritoneal mesothelioma in a large and unselected population-based case series. Cases (338) registered from 1990 to 2001 by 9 Italian regional mesothelioma registries contributing to the network of the National Mesothelioma Registry were followed until December 31, 2005. Univariate (Kaplan-Meier) and multivariate (Cox proportional hazards regression) analyses of survival were performed according to selected individual characteristics, including limited treatment information in a subset of 194 cases. The results were compared with those obtained in a parallel study on pleural mesothelioma cases. Epithelioid histotype, younger age at diagnosis and, to a lesser degree, gender (women), and being diagnosed in a hospital with a thoracic surgery unit positively and significantly affected survival. The effect of treatment was positive but not statistically significant. No trend in the risk of death according to calendar period of diagnosis was present. Peritoneal mesothelioma cases had shorter median survival time than pleural cases, but a larger proportion of long-term survivors. Survival patterns after peritoneal and pleural mesothelioma differed markedly. Treatment was not associated with a statistically significant improvement in survival, but our study included cases first diagnosed before the introduction of the most recent therapeutic approaches. This provides a large historical comparison for future studies on survival trends at the population level.
Dario Mirabelli; Sara Roberti; Manuela Gangemi; Rosalba Rosato; Fulvio Ricceri; Enzo Merler; Valerio Gennaro; Lucia Mangone; Giuseppe Gorini; Cristiana Pascucci; Domenica Cavone; Carmela Nicita; Pietro Gino Barbieri; Alessandro Marinaccio; Corrado Magnani; Fabio Montanaro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  124     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-08     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  194-200     Citation Subset:  IM    
Unit of Cancer Epidemiology, University of Turin, Turin, Italy.
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MeSH Terms
Mesothelioma / mortality*,  therapy
Middle Aged
Multivariate Analysis
Peritoneal Neoplasms / mortality*,  therapy
Proportional Hazards Models
Treatment Outcome

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