Document Detail


Survival of nerve allografts in sensitized rats treated with cyclosporin A.
MedLine Citation:
PMID:  6368766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effect of immunosuppressive treatment with cyclosporin A (Cy-A) on the survival of nerve allografts in sensitized rats. Nerve- or skin-sensitized untreated rats rejected a second nerve allograft of the same genotype as the first in an accelerated manner. In this situation, only a few host axons grew into the proximal 1 cm of a 4 cm-long nerve allograft. However, if sensitized rats were given Cy-A (10 mg/kg daily), the second nerve allograft survived, and numerous host axons regenerated through the 4-cm length of the allograft. These results indicated that Cy-A was an effective immunosuppressive agent in sensitized rats. We conclude that, in rats, donor-specific sensitization is not a contraindication to the use of nerve allografts to aid in the repair of injured nerve when Cy-A is used for immunosuppression.
Authors:
A A Zalewski; A K Gulati
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  60     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-02     Completed Date:  1984-05-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  828-34     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cyclosporins / therapeutic use*
Graft Survival / drug effects*
Immunization*
Male
Peroneal Nerve / pathology,  transplantation*
Rats
Skin Transplantation
Tibial Nerve / pathology,  transplantation*
Transplantation, Homologous / methods
Chemical
Reg. No./Substance:
0/Cyclosporins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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