Document Detail

Survival and major neonatal complications in infants born between 22 0/7 and 24 6/7 weeks of gestation (1999-2003).
MedLine Citation:
PMID:  16678782     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was undertaken to compare survival and morbidity until discharge in infants born after 22-23 versus 24 weeks' gestational age (GA). STUDY DESIGN: Cohort study of all infants 25 weeks or less, born in 3 tertiary perinatal centers (1999-2003). RESULTS: Of a total of 336 infants, 133 (40%) died before or immediately after birth without the provision of life support, 203 (60%) received active neonatal treatment. Infants with life support (n = 82 at 22 to 23 weeks, n = 121 at 24 weeks) differed with respect to antenatal steroid prophylaxis (44% vs 62%) and cesarean section rate (51% vs 71%). Survival was 67% compared with 82% (P = .016). The incidence of intraventricular hemorrhage III or greater or periventricular leukomalacia (15/15%), severe retinopathy of prematurity (18/15%), and chronic lung disease (40/47%) was similar in both GA groups. CONCLUSIONS: The provision of life support for extremely preterm infants increases their chance of survival without more neonatal morbidity.
Susanne Herber-Jonat; Andreas Schulze; Angela Kribs; Bernhard Roth; Wolfgang Lindner; Frank Pohlandt
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2006-05-05
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  195     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-07-24     Revised Date:  2007-05-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-22     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Divisison of Neonatology, Klinikum Grosshadern, University of Munich, Munich, Germany.
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MeSH Terms
Cause of Death
Cohort Studies
Gestational Age*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology*,  mortality
Life Support Care*
Logistic Models
Respiration, Artificial / statistics & numerical data
Survival Analysis
Comment In:
Am J Obstet Gynecol. 2007 May;196(5):e60; author reply e60-1   [PMID:  17466688 ]

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