Document Detail


Survival of lung adenocarcinoma patients with malignant pleural effusion.
MedLine Citation:
PMID:  23018906     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the era of targeted therapy, the association between lung adenocarcinoma patient survival and malignant pleural effusion (MPE) remains unclear. This study investigated the clinical characteristics, survival, and epidermal growth factor receptor (EGFR) mutation status of lung adenocarcinoma patients with MPE.During June 2005 to December 2010, consecutive pleural effusions were collected prospectively. Patient clinical characteristics, EGFR mutation status, and overall survival (OS) were analysed.We collected MPEs from 448 patients in stage IV lung adenocarcinoma at initial diagnosis. Median OS for patients with MPEs at initial diagnosis and following disease progression were 14.3 months and 21.4 months, respectively (p=0.001). There were 296 (66.1%) patient harbouring EGFR mutations; mutation rate among patients with MPEs at initial diagnosis and following disease progression were 68.2% and 56.6%, respectively (p=0.044); L858R mutation rate was also higher among the former (32.6% vs. 18.1%; p=0.009). Multivariate analysis revealed that patients who developed MPEs following disease progression, harboured EGFR mutations, and received EGFR-TKI therapy had longer OS. Patients in stage IV lung adenocarcinoma with MPEs at initial diagnosis have shorter overall survival and higher EGFR mutation rate, especially for L858R, than patients who develop MPEs following disease progression.
Authors:
Shang-Gin Wu; Chong-Jen Yu; Meng-Feng Tsai; Wei-Yu Liao; Chih-Hsin Yang; I-Shiow Jan; Pan-Chyr Yang; Jin-Yuan Shih
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
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