| Survival in thalassaemia major patients. | |
| | |
MedLine Citation:
|
PMID: 16864938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The present study evaluated the prognostic significance of Doppler-demonstrated left ventricular (LV) restrictive filling pattern (RFP) in patients with thalassaemia major (TM), which carries an adverse cardiovascular prognosis. METHODS AND RESULTS: The study group comprised 45 asymptomatic transfusion-dependent patients with TM and normal LV systolic function. All patients were chelated with desferrioxamine. They were regularly evaluated by clinical and Doppler-echocardiographic studies throughout the 15-year follow-up period. The patients were categorized into 2 groups according to baseline data: those with LVRFP and those with LV non-RFP. The incidence of cardiac death in both groups was analyzed. The impact of chelation therapy on the ventricular filling pattern and survival was also examined. Nineteen patients (42.2%) had LVRFP and 26 (57.8%) had LV non-RFP. During follow-up 11 patients died from cardiac causes; 8 of them (72.8%) initially had LVRFP and 3 (27.2%) had LV non-RFP. LVRFP was significantly associated with mortality (p=0.018). Poor compliance with chelation therapy was significantly associated with LVRFP (p=0.007) and cardiac mortality (p=0.003). CONCLUSIONS: LVRFP is an important predictor of cardiac mortality in patients with TM. Poor compliance with chelation therapy was significantly associated with both a RFP (p=0.007) and cardiac mortality (p=0.003). |
| | |
Authors:
|
Georgios K Efthimiadis; Helen P Hassapopoulou; Dimitrios D Tsikaderis; Haralambos I Karvounis; Georgios A Giannakoulas; Georgios E Parharidis; Georgios E Louridas |
Related Documents
:
|
12835658 - Doppler tissue imaging reveals systolic dysfunction in patients with hypertension and a... 145328 - Systolic anterior motion of the mitral valve in the absence of asymmetric septal hypert... 11035678 - Right ventricular dysfunction in adult severe cystic fibrosis. 1473028 - Quantitative scintigraphy of the sacroiliac joints. 16698218 - Blood and urine samples as useful sources for the direct detection of tuberculosis by p... 19130098 - Scoliosis and spine involvement in fibrous dysplasia of bone. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 70 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-07-25 Completed Date: 2006-09-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
|
Languages: eng Pagination: 1037-42 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Aristotle University, and Thalassemia Unit, AHEPA Hospital, Thessaloniki, Greece. efthymos@med.auth.gr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Chelation Therapy Death Deferoxamine / therapeutic use Echocardiography, Doppler Female Humans Longitudinal Studies Male Predictive Value of Tests Prognosis Proportional Hazards Models Siderophores / therapeutic use Survival Analysis Survival Rate Ventricular Dysfunction, Left / etiology*, ultrasonography* beta-Thalassemia / complications*, drug therapy, mortality* |
| Chemical | |
Reg. No./Substance:
|
0/Siderophores; 70-51-9/Deferoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of SstI polymorphism of the apolipoprotein CIII gene and environmental factors on risks of hy...
Next Document: Transcatheter closure of a ruptured sinus of valsalva aneurysm.