Document Detail


Survival in patients with poorly compressible leg arteries.
MedLine Citation:
PMID:  22261162     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study sought to compare survival of patients with poorly compressible arteries (PCA) to those with a normal ankle-brachial index (ABI) and those with peripheral arterial disease (PAD).
BACKGROUND: Limited data are available regarding survival in patients with PCA identified in the clinical setting by noninvasive lower extremity arterial evaluation.
METHODS: We conducted a historical cohort study of consecutive patients who underwent outpatient, noninvasive lower extremity arterial evaluation at the Mayo Clinic, Rochester, Minnesota, from January 1998 through December 2007, and who were followed for a mean duration of 5.8 ± 3.1 years. An ABI 1.00 to 1.30 was considered normal, PAD was defined as a resting or post-exercise ABI ≤0.90, and PCA defined as an ABI ≥1.4 and/or an ankle systolic blood pressure >255 mm Hg. Patients were followed for all-cause mortality through September 30, 2009.
RESULTS: Of 16,493 individuals (mean age 67.8 ± 13.0 years, 59% male); 29% had normal ABI, 54% had PAD, and 17% had PCA. During follow-up (mean duration 5.8 ± 3.1 years), 4,365 patients (26%) died. The percent alive at the end of the study period was 88%, 70%, and 60% for normal ABI, PAD, and PCA, respectively. After adjustment for age, sex, cardiovascular risk factors, comorbid conditions, and medication use, the hazard ratios (95% confidence intervals) of death associated with PCA were 2.0 (1.8 to 2.2) and 1.3 (1.2 to 1.4) compared with the normal ABI and PAD groups, respectively.
CONCLUSIONS: Patients identified by noninvasive vascular testing to have poorly compressible leg arteries have poor survival, worse than those with a normal ABI or those with PAD.
Authors:
Faisal A Arain; Zi Ye; Kent R Bailey; Qian Chen; Guanghui Liu; Cynthia L Leibson; Iftikhar J Kullo
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  59     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-20     Completed Date:  2012-03-12     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  400-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Ankle Brachial Index / mortality*
Female
Humans
Male
Middle Aged
Minnesota / epidemiology
Peripheral Arterial Disease / mortality*
Retrospective Studies
Vascular Calcification / mortality*
Vascular Stiffness*
Grant Support
ID/Acronym/Agency:
HL75794/HL/NHLBI NIH HHS; HL81331/HL/NHLBI NIH HHS; K12 HL083797/HL/NHLBI NIH HHS; K12 HL083797/HL/NHLBI NIH HHS; K12 HL083797-05/HL/NHLBI NIH HHS; R01 HL075794/HL/NHLBI NIH HHS; R01 HL075794-05/HL/NHLBI NIH HHS; U01 HL081331/HL/NHLBI NIH HHS; U01 HL081331-04/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
J Am Coll Cardiol. 2012 Aug 14;60(7):643; author reply 643-4   [PMID:  22878170 ]
J Am Coll Cardiol. 2012 Jan 24;59(4):408-9   [PMID:  22261163 ]

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