| Survival in New York Heart Association class IV heart failure patients treated with cardiac resynchronization therapy compared with patients on optimal pharmacological treatment. | |
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MedLine Citation:
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PMID: 20543199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Although the benefit of cardiac resynchronization therapy (CRT) in selected patients with heart failure is well established, its effect on mortality in New York Heart Association (NYHA) class IV patients remains unclear. Our study evaluated the effect of CRT on urgent transplant-free survival in NYHA class IV patients treated with CRT, compared with medication-only treatment. METHODS AND RESULTS: Forty NYHA class IV patients treated with CRT (80% men, 62.5% ischaemic, mean age of 65) were matched 1:1 by age, gender and aetiology of cardiomyopathy with patients treated with optimal medical therapy (OPT group). No significant differences were found between the groups in left ventricular diastolic diameter (71 +/- 6 vs. 73 +/- 9 mm), left ventricular systolic diameter (58 +/- 7 vs. 61 +/- 11 mm), and left ventricular ejection fraction (23 +/- 5 vs. 22 +/- 6%). Mean follow-up was 13.2 +/- 9.5 months for the CRT group and 17.3 +/- 11.6 months for the OPT group. Time to all-cause death or urgent transplantation [hazard ratios (HR), 1.29; 95% CI: 0.59-2.83; P = 0.52] or to cardiovascular death or urgent transplantation (HR, 1.53; 95% CI: 0.64-3.67; P = 0.34) was not reduced significantly in patients treated with CRT. CONCLUSION: In this study, CRT did not significantly improve survival of NYHA class IV heart failure patients compared with pharmacological therapy. |
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Authors:
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María Angeles Castel; Santiago Magnani; Lluís Mont; Eulalia Roig; David Tamborero; Francisco Méndez-Zurita; José Francisco Femenia; José María Tolosana; Félix Pérez-Villa; Josep Brugada |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-12 |
Journal Detail:
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Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Volume: 12 ISSN: 1532-2092 ISO Abbreviation: Europace Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-11-16 Revised Date: 2010-12-06 |
Medline Journal Info:
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Nlm Unique ID: 100883649 Medline TA: Europace Country: England |
Other Details:
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Languages: eng Pagination: 1136-40 Citation Subset: IM |
Affiliation:
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Thorax Clinic Institute, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Villarroel 170, Barcelona 08036, Spain. macastel@clilnic.ub.es |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Aged Angiotensin II Type 1 Receptor Blockers / therapeutic use Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Cardiac Pacing, Artificial / mortality*, statistics & numerical data* Death, Sudden, Cardiac / epidemiology Defibrillators, Implantable / statistics & numerical data Diuretics / therapeutic use Female Follow-Up Studies Heart Failure / drug therapy*, mortality* Heart Transplantation / mortality Humans Male Middle Aged New York / epidemiology Severity of Illness Index Societies, Medical |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Diuretics |
| Comments/Corrections | |
Comment In:
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Europace. 2010 Dec;12(12):1797; author reply 1797-8
[PMID:
20876275
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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