| Survival of human erythrocytes in primate animals. | |
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MedLine Citation:
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PMID: 7277466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The recovery and survival of small quantities of 51Cr-labelled human erythrocytes (RBCs) transfused to nonhuman primates were measured. In two chimpanzees all of the human RBCs circulated 15 min after transfusion and were subsequently removed from the animals' blood with a half-life (T1/2) of 1.6 and 2.4 days. In baboons and rhesus monkeys over 95% of the human RBCs were cleared within 15 min after injection. Animal species, rather than antibody characteristics or titer, was an important determinant of the human RBC survival. Transfusion of human RBCs to chimpanzees can thus be explored as a test system to study human erythrocyte disorders. |
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Authors:
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O Castro; W W Socha; J Moor-Jankowski |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of medical primatology Volume: 10 ISSN: 0047-2565 ISO Abbreviation: J. Med. Primatol. Publication Date: 1981 |
Date Detail:
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Created Date: 1981-11-24 Completed Date: 1981-11-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0320626 Medline TA: J Med Primatol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 55-60 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Transfusion* Erythrocyte Aging Erythrocyte Transfusion* Erythrocytes / physiology Half-Life Humans Macaca mulatta Pan troglodytes Papio Primates* Species Specificity Transplantation, Heterologous* |
| Grant Support | |
ID/Acronym/Agency:
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HL 15160/HL/NHLBI NIH HHS; HL 25392/HL/NHLBI NIH HHS; RR01082/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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