Document Detail


Survival of human erythrocytes in primate animals.
MedLine Citation:
PMID:  7277466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The recovery and survival of small quantities of 51Cr-labelled human erythrocytes (RBCs) transfused to nonhuman primates were measured. In two chimpanzees all of the human RBCs circulated 15 min after transfusion and were subsequently removed from the animals' blood with a half-life (T1/2) of 1.6 and 2.4 days. In baboons and rhesus monkeys over 95% of the human RBCs were cleared within 15 min after injection. Animal species, rather than antibody characteristics or titer, was an important determinant of the human RBC survival. Transfusion of human RBCs to chimpanzees can thus be explored as a test system to study human erythrocyte disorders.
Authors:
O Castro; W W Socha; J Moor-Jankowski
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medical primatology     Volume:  10     ISSN:  0047-2565     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  1981  
Date Detail:
Created Date:  1981-11-24     Completed Date:  1981-11-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Transfusion*
Erythrocyte Aging
Erythrocyte Transfusion*
Erythrocytes / physiology
Half-Life
Humans
Macaca mulatta
Pan troglodytes
Papio
Primates*
Species Specificity
Transplantation, Heterologous*
Grant Support
ID/Acronym/Agency:
HL 15160/HL/NHLBI NIH HHS; HL 25392/HL/NHLBI NIH HHS; RR01082/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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