| Survival and health in liveborn infants with transposition of great arteries--a population-based study. | |
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MedLine Citation:
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PMID: 18377460 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA). DESIGN: Population-based data from 7 European registries of congenital malformations (EUROCAT). RESULTS: Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10,000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development. CONCLUSIONS: In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable. |
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Authors:
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Ester Garne; Maria A Loane; Vera Nelen; Marian K Bakker; Blanca Gener; Lenore Abramsky; Marie-Claude Addor; Annette Queisser-Luft |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Congenital heart disease Volume: 2 ISSN: 1747-0803 ISO Abbreviation: Congenit Heart Dis Publication Date: 2007 May-Jun |
Date Detail:
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Created Date: 2008-04-01 Completed Date: 2008-06-19 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 101256510 Medline TA: Congenit Heart Dis Country: United States |
Other Details:
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Languages: eng Pagination: 165-9 Citation Subset: IM |
Affiliation:
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Paediatric Department, Kolding Hospital, Kolding, Denmark. egarne@health.sdu.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Surgical Procedures Follow-Up Studies Humans Infant Welfare* Infant, Newborn Live Birth* Prenatal Diagnosis Prevalence Prostaglandins / therapeutic use Registries Survival Analysis Transposition of Great Vessels / epidemiology, mortality*, physiopathology*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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