Document Detail

Survival and health in liveborn infants with transposition of great arteries--a population-based study.
MedLine Citation:
PMID:  18377460     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA).
DESIGN: Population-based data from 7 European registries of congenital malformations (EUROCAT).
RESULTS: Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10,000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development.
CONCLUSIONS: In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.
Ester Garne; Maria A Loane; Vera Nelen; Marian K Bakker; Blanca Gener; Lenore Abramsky; Marie-Claude Addor; Annette Queisser-Luft
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congenital heart disease     Volume:  2     ISSN:  1747-0803     ISO Abbreviation:  Congenit Heart Dis     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-06-19     Revised Date:  2011-05-05    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-9     Citation Subset:  IM    
Paediatric Department, Kolding Hospital, Kolding, Denmark.
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MeSH Terms
Cardiac Surgical Procedures
Follow-Up Studies
Infant Welfare*
Infant, Newborn
Live Birth*
Prenatal Diagnosis
Prostaglandins / therapeutic use
Survival Analysis
Transposition of Great Vessels / epidemiology,  mortality*,  physiopathology*,  therapy
Reg. No./Substance:

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