| Survival of fetuses with 45,X: an instructive case and an hypothesis. | |
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MedLine Citation:
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PMID: 1554022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The high (greater than 95%) fetal loss rate of 45,X embryos and fetuses has led to the suggestion that fetal survival with this karyotype requires the presence of mosaicism. However, in many instances, even given a "mild Ullrich-Turner syndrome" phenotype, mosaicism is not detected. In a pregnancy studied for advanced maternal age, CVS cultured cells showed 65% 45,X and 35% 46,X,r(X). After termination, 2 fetal tissues showed 95% 45,X cells. It is suggested that infants with the 45,X karyotype likely had mosaicism for a structurally abnormal X or Y chromosome during embryogenesis, but the abnormal cell line disappeared prior to birth. |
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Authors:
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T E Kelly; J E Ferguson; W Golden |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of medical genetics Volume: 42 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-04-30 Completed Date: 1992-04-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 825-6 Citation Subset: IM |
Affiliation:
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Division of Medical Genetics, University of Virginia School of Medicine, Charlottesville. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aneuploidy Cells, Cultured Female Fetal Viability* Humans Karyotyping Mosaicism Pregnancy Turner Syndrome / genetics*, mortality X Chromosome* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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