Document Detail


Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases.
MedLine Citation:
PMID:  22547843     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This retrospective study reports the survival time [onset of congestive heart failure (CHF) to death from any cause] of 21 dogs with mitral regurgitation (MR) and CHF treated with a combination of furosemide, angiotensin-converting enzyme inhibitor (ACEI, benazepril, or enalapril), pimobendan, spironolactone, and amlodipine. Baseline echocardiographic data: end-systolic and end-diastolic volume indices (ESVI and EDVI), left atrium to aorta ratio (LA/Ao), and regurgitant fraction (RF) are reported. Median survival time (MST) was 430 d. Initial dosage of furosemide (P = 0.0081) and LA/Ao (P = 0.042) were negatively associated with survival. Baseline echocardiographic indices (mean ± standard deviation) were 40.24 ± 16.76 for ESVI, 161.48 ± 44.49 mL/m(2) for EDVI, 2.11 ± 0.75 for LA/Ao, and 64.71 ± 16.85% for RF. Combining furosemide, ACEI, pimobendan, spironolactone, and amlodipine may result in long survival times in dogs with MR and CHF. Severity of MR at onset of CHF is at least moderate.
Authors:
Eric de Madron; Jonathan N King; Günther Strehlau; Regina Valle White
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian veterinary journal. La revue vétérinaire canadienne     Volume:  52     ISSN:  0008-5286     ISO Abbreviation:  Can. Vet. J.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2012-05-01     Completed Date:  2012-06-14     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0004653     Medline TA:  Can Vet J     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1219-25     Citation Subset:  IM    
Affiliation:
Alta Vista Animal Hospital, Ottawa, Ontario, Canada. ericdem@magma.ca
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Animals
Benzazepines / therapeutic use
Cardiotonic Agents / therapeutic use*
Death, Sudden, Cardiac / prevention & control,  veterinary
Dog Diseases / drug therapy,  mortality*,  ultrasonography
Dogs
Drug Therapy, Combination / veterinary
Enalapril / therapeutic use
Female
Furosemide / therapeutic use
Heart Failure / drug therapy,  etiology,  mortality,  veterinary*
Male
Mitral Valve Insufficiency / complications,  drug therapy,  mortality,  veterinary*
Pyridazines / therapeutic use
Retrospective Studies
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzazepines; 0/Cardiotonic Agents; 0/Pyridazines; 34AP3BBP9T/pimobendan; 54-31-9/Furosemide; 75847-73-3/Enalapril; UDM7Q7QWP8/benazepril
Comments/Corrections

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