| Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases. | |
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MedLine Citation:
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PMID: 22547843 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This retrospective study reports the survival time [onset of congestive heart failure (CHF) to death from any cause] of 21 dogs with mitral regurgitation (MR) and CHF treated with a combination of furosemide, angiotensin-converting enzyme inhibitor (ACEI, benazepril, or enalapril), pimobendan, spironolactone, and amlodipine. Baseline echocardiographic data: end-systolic and end-diastolic volume indices (ESVI and EDVI), left atrium to aorta ratio (LA/Ao), and regurgitant fraction (RF) are reported. Median survival time (MST) was 430 d. Initial dosage of furosemide (P = 0.0081) and LA/Ao (P = 0.042) were negatively associated with survival. Baseline echocardiographic indices (mean ± standard deviation) were 40.24 ± 16.76 for ESVI, 161.48 ± 44.49 mL/m(2) for EDVI, 2.11 ± 0.75 for LA/Ao, and 64.71 ± 16.85% for RF. Combining furosemide, ACEI, pimobendan, spironolactone, and amlodipine may result in long survival times in dogs with MR and CHF. Severity of MR at onset of CHF is at least moderate. |
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Authors:
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Eric de Madron; Jonathan N King; Günther Strehlau; Regina Valle White |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian veterinary journal. La revue vétérinaire canadienne Volume: 52 ISSN: 0008-5286 ISO Abbreviation: Can. Vet. J. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-05-01 Completed Date: 2012-06-14 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0004653 Medline TA: Can Vet J Country: Canada |
Other Details:
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Languages: eng Pagination: 1219-25 Citation Subset: IM |
Affiliation:
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Alta Vista Animal Hospital, Ottawa, Ontario, Canada. ericdem@magma.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use* Animals Benzazepines / therapeutic use Cardiotonic Agents / therapeutic use* Death, Sudden, Cardiac / prevention & control, veterinary Dog Diseases / drug therapy, mortality*, ultrasonography Dogs Drug Therapy, Combination / veterinary Enalapril / therapeutic use Female Furosemide / therapeutic use Heart Failure / drug therapy, etiology, mortality, veterinary* Male Mitral Valve Insufficiency / complications, drug therapy, mortality, veterinary* Pyridazines / therapeutic use Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzazepines; 0/Cardiotonic Agents; 0/Pyridazines; 34AP3BBP9T/pimobendan; 54-31-9/Furosemide; 75847-73-3/Enalapril; UDM7Q7QWP8/benazepril |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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