Document Detail

Survival, cranial ultrasound and cerebral palsy in very low birthweight infants: 1980s versus 1990s.
MedLine Citation:
PMID:  10723683     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the changes in the rates of survival, cranial ultrasound abnormalities and cerebral palsy in very low birthweight (VLBW) (birthweight 500-1499 g) infants between the early 1980s and the early 1990s. METHODOLOGY: A cohort study of consecutive VLBW live births in one tertiary perinatal hospital during two distinct eras was performed at The Royal Women's Hospital, Melbourne, a level-III perinatal centre. Consecutive VLBW infants born over the 18-month period from 1 October 1980 (n = 222), and over the 12-month period from 1 January 1992 (n = 202) were identified. The main outcome measures were the proportions of live births surviving to 5 years of age, rates of cranial ultrasound abnormalities, and rates of cerebral palsy at 5 years of age. RESULTS: Over the 18 months from 1 October 1980, 68% (150/222) VLBW live births survived to 5 years of age. The survival rate rose substantially to 82% (165/202) during 1992 (odds ratio 2.1, 95% confidence interval 1.4-3.2). The survival rate increased over time more for those of 500-999 g birthweight than for those of 1000-1499 g birthweight. The rates of cerebroventricular haemorrhage (CVH) were similar inlive births and survivors from both eras, as were the rates of cerebral palsy (7.5% in 1980-82; 7.8% in 1992) in survivors seen at 5 years of age. The positive predictive value of CVH for cerebral palsy was low, but cystic periventricular leucomalacia was followed by cerebral palsy in seven of eight survivors from the 1992 cohort. CONCLUSIONS: Despite the increasing survival rate with improvements in perinatal care, including more antenatal steroid therapy and the introduction of exogenous surfactant, the rates of CVH and of cerebral palsy in survivors have not diminished.
L W Doyle; F R Betheras; G W Ford; N M Davis; C Callanan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  36     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-04-04     Completed Date:  2000-04-04     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
Division of Newborn Services, Royal Women's Hospital, Victoria, Australia.
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MeSH Terms
Australia / epidemiology
Brain / abnormalities*
Cerebral Hemorrhage / diagnosis,  epidemiology*
Cerebral Palsy / diagnosis,  epidemiology*
Child, Preschool
Gestational Age
Infant Mortality*
Infant, Newborn
Infant, Very Low Birth Weight*
Outcome Assessment (Health Care)
Perinatal Care
Survival Rate
Survivors / statistics & numerical data*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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