Document Detail

Survival comparison of the Ross procedure and mechanical valve replacement with optimal self-management anticoagulation therapy: propensity-matched cohort study.
MedLine Citation:
PMID:  21173349     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is suggested that in young adults the Ross procedure results in better late patient survival compared with mechanical prosthesis implantation. We performed a propensity score-matched study that assessed late survival in young adult patients after a Ross procedure versus that after mechanical aortic valve replacement with optimal self-management anticoagulation therapy.
METHODS AND RESULTS: We selected 918 Ross patients and 406 mechanical valve patients 18 to 60 years of age without dissection, aneurysm, or mitral valve replacement who survived an elective procedure (1994 to 2008). With the use of propensity score matching, late survival was compared between the 2 groups. Two hundred fifty-three patients with a mechanical valve (mean follow-up, 6.3 years) could be propensity matched to a Ross patient (mean follow-up, 5.1 years). Mean age of the matched cohort was 47.3 years in the Ross procedure group and 48.0 years in the mechanical valve group (P=0.17); the ratio of male to female patients was 3.2 in the Ross procedure group and 2.7 in the mechanical valve group (P=0.46). Linearized all-cause mortality rate was 0.53% per patient-year in the Ross procedure group compared with 0.30% per patient-year in the mechanical valve group (matched hazard ratio, 1.86; 95% confidence interval, 0.58 to 5.91; P=0.32). Late survival was comparable to that of the general German population.
CONCLUSIONS: In comparable patients, there is no late survival difference in the first postoperative decade between the Ross procedure and mechanical aortic valve implantation with optimal anticoagulation self-management. Survival in these selected young adult patients closely resembles that of the general population, possibly as a result of highly specialized anticoagulation self-management, better timing of surgery, and improved patient selection in recent years.
M Mostafa Mokhles; Heinrich Körtke; Ulrich Stierle; Otto Wagner; Efstratios I Charitos; Ad J J C Bogers; Jan Gummert; Hans-Hinrich Sievers; Johanna J M Takkenberg
Related Documents :
21358249 - Thrust plate prosthesis for proximal femoral deformity: a series of 15 patients.
21498279 - High incidence of nephropathy in neurosurgical patients after intra-arterial administra...
21275529 - Tunica albuginea reefing: a novel technique for the treatment of erectile dysfunction.
1358129 - Clinical aspects and distribution of immunologically active cells in the nasal mucosa o...
21551479 - Beneficial effect of pioglitazone on the outcome of catheter ablation in patients with ...
21418249 - Normal pulmonary veins anatomy is associated with better af-free survival after cryoabl...
10609499 - Hormone replacement therapy after uterine leiomyosarcoma treatment. case reports.
11506169 - Orthodontic treatment of a mildly crowded malocclusion using the invisalign system.
23571079 - Endovenous ablation with concomitant phlebectomy is a safe and effective method of trea...
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-12-20
Journal Detail:
Title:  Circulation     Volume:  123     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  AIM; IM    
Department of Cardiothoracic Surgery, Erasmus Medical Center, Room Bd 575, PO Box 2040, 3000 CA Rotterdam, the Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anticoagulants / therapeutic use*
Aortic Diseases / drug therapy,  surgery
Cardiac Surgical Procedures / standards
Cohort Studies
Follow-Up Studies
Heart Valve Diseases / drug therapy*,  surgery*
Heart Valve Prosthesis Implantation / standards*
Middle Aged
Propensity Score*
Prospective Studies
Self Care / standards*
Treatment Outcome
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Randomized comparison of final kissing balloon dilatation versus no final kissing balloon dilatation...
Next Document:  Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyo...