| Survival benefit conferred by topical antimicrobial preparations in burn patients: a historical perspective. | |
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MedLine Citation:
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PMID: 15187754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Topical antimicrobial agents have proven efficacy in preventing life-threatening invasive burn wound infection. Under wartime or mass-casualty conditions, however, there may be an inadequate supply of these agents. This study aimed to identify those patients most likely to benefit therefrom. METHODS: Logistical regression analysis of data from the U.S. Army Burn Center was performed. Mortality data for the period immediately preceding the introduction of topical mafenide acetate (MA) (1950-1963) were compared with data for the subsequent period (1964-1968). During the second period, MA was routinely applied but treatment was otherwise similar. The mortality decrement attributed to MA was determined for various ages and burn sizes. RESULTS: For patients of combatant age (20-50 years), MA was associated with a greater than 10% reduction in mortality for those with burns of 40-79% of the total body surface area (TBSA). Only a minimal effect on mortality was noted for those patients with burns smaller than 40% or greater than 79%. CONCLUSIONS: When resources are limited, topical therapy (specifically, MA) is likely to confer the greatest survival benefit for combatants with burns of 40-79% TBSA. |
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Authors:
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Timothy P La H Brown; Leopoldo C Cancio; Albert T McManus; Arthur D Mason |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of trauma Volume: 56 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-06-10 Completed Date: 2004-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: United States |
Other Details:
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Languages: eng Pagination: 863-6 Citation Subset: AIM; IM |
Affiliation:
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The Burns Unit, Middlemore Hospital, Auckland, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Anti-Infective Agents, Local / administration & dosage, therapeutic use* Burns / drug therapy, mortality* Disaster Planning* Humans Logistic Models Mafenide / administration & dosage, therapeutic use* Male Middle Aged Military Personnel* Retrospective Studies Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 138-39-6/Mafenide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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