| Survival after surgery for congenital heart defects: does reduced early mortality predict improved long-term survival? | |
MedLine Citation:
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PMID: 16092458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The objectives of this study were 1) to compare early mortality (first 30 d after surgery) and long-term survival between two cohorts of patients operated on for congenital cardiac defects, and 2) to evaluate the impact of possible changes in early mortality on long-term survival. METHODS: 945 patients with congenital cardiac defects, born in 1990-1999 and operated on in the same period were examined in a retrospective cohort study. The patients were divided into three groups: "univentricular cardiac defects", "severe cardiac defects" and "less severe cardiac defects". The study population was divided into two cohorts: group 1 included patients born and operated on in 1990-1994; group 2 included patients born and operated on in 1995-1999. The survival patterns in the two groups were compared. RESULTS: For all patients, except those with univentricular cardiac defects, early mortality (30 d after surgery) was reduced. Among patients with severe cardiac defects, early mortality was reduced from 18.6% in group 1 to 2.9% in group 2. Among patients with less severe cardiac defects, early mortality was reduced from 6.2% to 1.9%. The improved outcome was maintained during the following 5 y. Overall relative risk of death during follow-up was reduced to 0.31 (95% CI: 0.15-0.56) for patients with severe cardiac defects, and to 0.53 (95% CI: 0.31-0.93) for patients with less severe cardiac defects born and operated on in 1995-1999. CONCLUSION: Early mortality has been substantially reduced in congenital heart defect patients, and corresponds with significantly improved long-term survival. |
Authors:
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Leif Eskedal; Peter Skjalg Hagemo; Anne Eskild; Geir Aamodt; Kerry S Seiler; Erik Thaulow |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 94 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-08-11 Completed Date: 2005-08-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 438-43 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Sørlandet Hospital, Kristiansand, Norway. leif.eskedal@sshf.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Female Heart Defects, Congenital / mortality*, surgery* Humans Infant Infant, Newborn Male Retrospective Studies Survival Rate |
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