Document Detail

Survival after application of automatic external defibrillators before arrival of the emergency medical system: evaluation in the resuscitation outcomes consortium population of 21 million.
MedLine Citation:
PMID:  20394876     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this study was to assess the effectiveness of contemporary automatic external defibrillator (AED) use.
BACKGROUND: In the PAD (Public Access Defibrillation) trial, survival was doubled by focused training of lay volunteers to use an AED in high-risk public settings.
METHODS: We performed a population-based cohort study of persons with nontraumatic out-of-hospital cardiac arrest before emergency medical system (EMS) arrival at Resuscitation Outcomes Consortium (ROC) sites between December 2005 and May 2007. Multiple logistic regression was used to assess the independent association between AED application and survival to hospital discharge.
RESULTS: Of 13,769 out-of-hospital cardiac arrests, 4,403 (32.0%) received bystander cardiopulmonary resuscitation but had no AED applied before EMS arrival, and 289 (2.1%) had an AED applied before EMS arrival. The AED was applied by health care workers (32%), lay volunteers (35%), police (26%), or unknown (7%). Overall survival to hospital discharge was 7%. Survival was 9% (382 of 4,403) with bystander cardiopulmonary resuscitation but no AED, 24% (69 of 289) with AED application, and 38% (64 of 170) with AED shock delivered. In multivariable analyses adjusting for: 1) age and sex; 2) bystander cardiopulmonary resuscitation performed; 3) location of arrest (public or private); 4) EMS response interval; 5) arrest witnessed; 6) initial shockable or not shockable rhythm; and 7) study site, AED application was associated with greater likelihood of survival (odds ratio: 1.75; 95% confidence interval: 1.23 to 2.50; p < 0.002). Extrapolating this greater survival from the ROC EMS population base (21 million) to the population of the U.S. and Canada (330 million), AED application by bystanders seems to save 474 lives/year.
CONCLUSIONS: Application of an AED in communities is associated with nearly a doubling of survival after out-of-hospital cardiac arrest. These results reinforce the importance of strategically expanding community-based AED programs.
Myron L Weisfeldt; Colleen M Sitlani; Joseph P Ornato; Thomas Rea; Tom P Aufderheide; Daniel Davis; Jonathan Dreyer; Erik P Hess; Jonathan Jui; Justin Maloney; George Sopko; Judy Powell; Graham Nichol; Laurie J Morrison;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  55     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-06-15     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1713-20     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Johns Hopkins University, Baltimore, Maryland 21287, USA.
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MeSH Terms
Canada / epidemiology
Cardiopulmonary Resuscitation / instrumentation*
Electric Countershock / instrumentation*
Emergency Medical Services / methods*
Equipment Design
Heart Arrest / mortality*,  therapy
Middle Aged
Population Surveillance*
Prospective Studies
Survival Rate / trends
Treatment Outcome
United States / epidemiology
Grant Support
5U01 HL077863/HL/NHLBI NIH HHS; HL077865/HL/NHLBI NIH HHS; HL077866/HL/NHLBI NIH HHS; HL077867/HL/NHLBI NIH HHS; HL077871/HL/NHLBI NIH HHS; HL077872/HL/NHLBI NIH HHS; HL077873/HL/NHLBI NIH HHS; HL077881/HL/NHLBI NIH HHS; HL077885/HL/NHLBI NIH HHS; HL077887/HL/NHLBI NIH HHS; HL077908/HL/NHLBI NIH HHS; U01 HL077863-06/HL/NHLBI NIH HHS; U01 HL077863-06S2/HL/NHLBI NIH HHS; //Canadian Institutes of Health Research

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