| Survival after AIDS diagnosis in Italy, 1999-2006: a population-based study. | |
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MedLine Citation:
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PMID: 19448558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To provide survival estimates of Italian people with AIDS (PWA) in the highly active antiretroviral therapy era and to identify prognostic factors at diagnosis and illnesses present at death. DESIGN: Longitudinal study with all-cause mortality as end point. METHODS: The vital status and illnesses present at death of the 9662 Italian PWA diagnosed from 1999 to 2005 were evaluated through a record linkage with the Italian mortality database. The survival was estimated through Kaplan-Meier method, whereas hazard ratios were computed to identify prognostic factors in the first 12 months or later. RESULTS: 80.6% of PWA survived 1 year, 75.2% 2 years, and 66.4% 5 years. Elevated death risks emerged among older individuals, injection drug users, and those with a CD4 cell count <200. Non-Hodgkin lymphoma at AIDS diagnosis was the strongest negative prognostic factor, particularly in the first 12 months after AIDS (hazard ratio = 9.2, for primary brain lymphoma). At death, non-AIDS-defining illnesses increased from 38.4% in 1999 to 56.9% in 2006, with non-AIDS-defining cancers rising from 3.7% to 8.7%. CONCLUSIONS: Our study documented the prolonged survival of Italian PWA, the strong impact of non-Hodgkin lymphoma on mortality, and the increasing frequency of non-AIDS-defining illnesses at death. |
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Authors:
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Diego Serraino; Antonella Zucchetto; Barbara Suligoi; Silvia Bruzzone; Laura Camoni; Stefano Boros; Angela De Paoli; Luigino Dal Maso; Silvia Franceschi; Giovanni Rezza |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 52 ISSN: 1525-4135 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-25 Completed Date: 2009-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 99-105 Citation Subset: IM; X |
Affiliation:
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Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy. serrainod@cro.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications,
diagnosis*,
drug therapy,
mortality* Adult Antiretroviral Therapy, Highly Active / mortality Female Humans Italy / epidemiology Longitudinal Studies Lymphoma, Non-Hodgkin / etiology, mortality Male Middle Aged Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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