| Survival benefit of early infant antiretroviral therapy is compromised when diagnosis is delayed. | |
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MedLine Citation:
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PMID: 22544051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Late presentation is common among African HIV-1-infected infants. Incidence and correlates of mortality were examined in 99 infants with HIV-1 diagnosis by 5 months of age. Twelve-month survival was 66.8% (95% confidence interval: 55.9-75.6%). World Health Organization stage 3 or 4, underweight, wasting, microcephaly, low hemoglobin, pneumonia and gastroenteritis predicted mortality. Early HIV-1 diagnosis with antiretroviral therapy before symptomatic disease is critical for infant survival. |
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Authors:
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Dalton Wamalwa; Sarah Benki-Nugent; Agnes Langat; Ken Tapia; Evelyn Ngugi; Jennifer A Slyker; Barbra A Richardson; Grace C John-Stewart |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 31 ISSN: 1532-0987 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-14 Completed Date: 2012-10-02 Revised Date: 2013-04-25 |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: United States |
Other Details:
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Languages: eng Pagination: 729-31 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, University of Nairobi, Nairobi, Kenya. dalton@africaonline.co.ke |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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administration & dosage* Antiretroviral Therapy, Highly Active / methods* Delayed Diagnosis Female HIV Infections / diagnosis*, drug therapy*, mortality, virology HIV-1 / isolation & purification Humans Infant Male Survival Analysis |
| Grant Support | |
ID/Acronym/Agency:
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K01 AI087369/AI/NIAID NIH HHS; K24 HD054314/HD/NICHD NIH HHS; P30 AI027757/AI/NIAID NIH HHS; P30 AI027757/AI/NIAID NIH HHS; R01 HD023412/HD/NICHD NIH HHS; R01 HD23412/HD/NICHD NIH HHS; R01 TW007632/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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