Document Detail


Survival benefit of early infant antiretroviral therapy is compromised when diagnosis is delayed.
MedLine Citation:
PMID:  22544051     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Late presentation is common among African HIV-1-infected infants. Incidence and correlates of mortality were examined in 99 infants with HIV-1 diagnosis by 5 months of age. Twelve-month survival was 66.8% (95% confidence interval: 55.9-75.6%). World Health Organization stage 3 or 4, underweight, wasting, microcephaly, low hemoglobin, pneumonia and gastroenteritis predicted mortality. Early HIV-1 diagnosis with antiretroviral therapy before symptomatic disease is critical for infant survival.
Authors:
Dalton Wamalwa; Sarah Benki-Nugent; Agnes Langat; Ken Tapia; Evelyn Ngugi; Jennifer A Slyker; Barbra A Richardson; Grace C John-Stewart
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  31     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-14     Completed Date:  2012-10-02     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  729-31     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, University of Nairobi, Nairobi, Kenya. dalton@africaonline.co.ke
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MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / administration & dosage*
Antiretroviral Therapy, Highly Active / methods*
Delayed Diagnosis
Female
HIV Infections / diagnosis*,  drug therapy*,  mortality,  virology
HIV-1 / isolation & purification
Humans
Infant
Male
Survival Analysis
Grant Support
ID/Acronym/Agency:
K01 AI087369/AI/NIAID NIH HHS; K01 NS080637/NS/NINDS NIH HHS; K24 HD054314/HD/NICHD NIH HHS; K24 HD054314/HD/NICHD NIH HHS; P30 AI027757/AI/NIAID NIH HHS; P30 AI027757/AI/NIAID NIH HHS; R01 HD023412/HD/NICHD NIH HHS; R01 HD023412/HD/NICHD NIH HHS; R01 HD23412/HD/NICHD NIH HHS; R01 TW007632/TW/FIC NIH HHS; R01 TW007632/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Anti-HIV Agents
Comments/Corrections

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