| Survial of fasted rats exposed to altitude. | |
| | |
MedLine Citation:
|
PMID: 1021222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Rats fasted for 48-96h before exposure were shown to have a longer survival time at groups 33,500 ft (1 ft = 0.305 m) simulated altitude than nonfasted controls. Although both become hypothermic at 33500 ft, colonic temperatures of the fasted rats were not sufficiently lower than those of nonfasted animals to explain the difference in survival time. The injection of glucose and insulin before exposure almost completely eliminated the protection afforded by fasting, whereas glucose alone had no effect on survival. It is therefore suggested that an alteration in carbohydrate metabolism, possibly in combination with other starvation-induced changes, allowed fasted rats to survive at 33500 ft until declining body temperature reduced metabolic rate to a level compatible with oxygen supply. |
| | |
Authors:
|
W S Myles |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Canadian journal of physiology and pharmacology Volume: 54 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1976 Dec |
Date Detail:
|
Created Date: 1977-05-12 Completed Date: 1977-05-12 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
|
Languages: eng Pagination: 883-6 Citation Subset: IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Altitude Sickness
/
drug therapy,
metabolism,
mortality* Animals Anoxia / mortality* Blood Glucose / metabolism Body Temperature Fasting* Glucose / pharmacology Insulin / pharmacology Male Rats Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of alterations in ambient temperature on blood flow in the skin.
Next Document: Vasopressin contamination as a cause of some apparent renal actions of prolactin.