Document Detail

Survey of prothrombin time in National External Quality Assessment Scheme exercises (1980-87).
MedLine Citation:
PMID:  3366918     Owner:  NLM     Status:  MEDLINE    
National External Quality Assessment Scheme surveys on the prothrombin time test carried out in hospitals in the United Kingdom have been performed at regular intervals since 1972. Performance has been assessed by comparing observed variability between hospitals with that predicted by a statistical model. The model was based on results from 53 survey plasmas issued between 1980 and 1987. These showed a linear correlation between logarithms of mean and standard deviation of reported ratios. Precision improved until the human brain thromboplastin, Manchester Comparative Reagent, was withdrawn in January 1986. There then followed a pronounced overall deterioration which, by October 1987, had not corrected to the levels achieved by 1985. When the recent results from 1986-87 were analysed according to Quick test reagent only one reagent (ISI 1.1) showed an improvement in precision. Performance of the other Quick test reagents, all with higher ISI values, had not regained the standards of precision previously achieved by the human brain reagent.
L Poller; D A Taberner; J M Thomson; K V Darby
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  41     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-06-20     Completed Date:  1988-06-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  361-4     Citation Subset:  AIM; IM    
United Kingdom Reference Laboratory for Anticoagulant Reagents and Control, Withington Hospital, Manchester.
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MeSH Terms
Great Britain
Laboratories, Hospital
Prothrombin Time*
Quality Control
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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