| Survey on the management of skin toxicity associated with EGFR inhibitors amongst French Physicians. | |
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MedLine Citation:
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PMID: 22211860 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background Epidermal growth factor receptor (EGFR) inhibitors are part of the therapeutic arsenal available for advanced cancer. However, they are frequently associated with cutaneous side-effects, which can hamper compliance, lead to treatment refusal and impair quality of life. Objective To know the attitudes of French oncologists who deal with this skin toxicity. This work is one of the steps to build a therapeutic algorithm of side-effects induced by EGFR inhibitors taking both evidence-based medicine and standard practices into account. Methods Physicians completed a questionnaire as part of regional meetings, before any discussion. Questions concerned the management of 11 clinical situations in the context of EGFR inhibitor prescription. Results Sixty-seven questionnaires were analysed. The collaboration with dermatologists was especially planned for persisting or worsening lesions beyond 2 weeks, but never considered at the time of the introduction of targeted therapy. The results demonstrated the difficulties encountered in diagnosing and grading skin lesions. Attitudes of oncologists were uniform for preventive care and management of mild lesions for which moisturizing and cyclines were widely prescribed. Significant differences appeared in the treatment of less typical cases such as the involvement of skin appendages, secondary infections of folliculitis or cases associated with radiodermatitis. Discrepancies existed also for what to do in relation with maintenance or interruption of EGFR inhibitor mainly if they were responsible for severe lesions. Conclusion This original survey emphasizes the interest of greater multidisciplinary collaboration and the necessity to harmonize practice. |
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Authors:
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L Peuvrel; C Bachmeyer; Z Reguiai; J B Bachet; T André; R J Bensadoun; O Bouché; M Ychou; B Dréno; |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-3 |
Journal Detail:
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Title: Journal of the European Academy of Dermatology and Venereology : JEADV Volume: - ISSN: 1468-3083 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9216037 Medline TA: J Eur Acad Dermatol Venereol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology. |
Affiliation:
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Department of Dermato- Cancerology CHU de Nantes, Nantes, France CIC biotherapy, INSERM 0305, Nantes, France Internal Medicine, Hôpital Tenon, APHP, Paris, France Dermatology, CHU Robert Debré, Reims, France Hepato-gastro-enterology, Groupe Hospitalier Pitié-Salpêtrière - APHP, Université Pierre & Marie Curie, Paris, France GERCOR, Paris, France Department of Medical Oncology, Hôpital St Antoine, APHP, Université Pierre & Marie Curie, Paris, France Radiotherapeutic oncology, CHU de Poitiers, Poitiers, France Hepato-gastro-enterology and gastro-intestinal oncology, CHU Robert Debré, Reims, France CRLC Val d'Aurelle, Montpellier, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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