| Survey of cord blood hemoglobin in Japan and identification of two new gamma chain variants. | |
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MedLine Citation:
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PMID: 6163752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two gamma chain variants were discovered during a survey of 2,569 cord bloods of Japanese. One was the first case with mutation of the T-gamma chain, i. e. Hb F Yamaguchi or gamma 80 (EF 4) Asp leads to Asn (75 Thr, 136 Ala). It comprised 33.6% of Hb F, an unusually high percentage for a gamma chain variant. The other concerned with the first report of substitution at E 16, i. e. Hb F Iwata or gamma 72 (E 16) Gly leads to Arg (75 Ile, 136 Ala). It comprised 11.0% which is comparable to the values usually reported in an A-gamma chain variant. No clinical consequences have been observed in association with the hemoglobin variants. |
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Authors:
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K Fuyuno; T Torigoe; Y Ohba; M Matsuoka; T Miyaji |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hemoglobin Volume: 5 ISSN: 0363-0269 ISO Abbreviation: Hemoglobin Publication Date: 1981 |
Date Detail:
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Created Date: 1981-06-23 Completed Date: 1981-06-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7705865 Medline TA: Hemoglobin Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 139-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Amino Acids / analysis Female Fetal Blood / analysis* Fetal Hemoglobin* / isolation & purification Genetic Variation Hemoglobins, Abnormal* / isolation & purification Humans Japan Peptide Fragments / analysis Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Hemoglobins, Abnormal; 0/Peptide Fragments; 77907-57-4/hemoglobin F Iwata; 77907-58-5/hemoglobin F Yamaguchi; 9034-63-3/Fetal Hemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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