Document Detail


Survey of cord blood hemoglobin in Japan and identification of two new gamma chain variants.
MedLine Citation:
PMID:  6163752     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two gamma chain variants were discovered during a survey of 2,569 cord bloods of Japanese. One was the first case with mutation of the T-gamma chain, i. e. Hb F Yamaguchi or gamma 80 (EF 4) Asp leads to Asn (75 Thr, 136 Ala). It comprised 33.6% of Hb F, an unusually high percentage for a gamma chain variant. The other concerned with the first report of substitution at E 16, i. e. Hb F Iwata or gamma 72 (E 16) Gly leads to Arg (75 Ile, 136 Ala). It comprised 11.0% which is comparable to the values usually reported in an A-gamma chain variant. No clinical consequences have been observed in association with the hemoglobin variants.
Authors:
K Fuyuno; T Torigoe; Y Ohba; M Matsuoka; T Miyaji
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hemoglobin     Volume:  5     ISSN:  0363-0269     ISO Abbreviation:  Hemoglobin     Publication Date:  1981  
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7705865     Medline TA:  Hemoglobin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Amino Acids / analysis
Female
Fetal Blood / analysis*
Fetal Hemoglobin* / isolation & purification
Genetic Variation
Hemoglobins, Abnormal* / isolation & purification
Humans
Japan
Peptide Fragments / analysis
Pregnancy
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Hemoglobins, Abnormal; 0/Peptide Fragments; 77907-57-4/hemoglobin F Iwata; 77907-58-5/hemoglobin F Yamaguchi; 9034-63-3/Fetal Hemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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