| Survey of Japanese infants younger than 3 months who were treated with oseltamivir for influenza: Safety of oseltamivir treatment. | |
| | |
MedLine Citation:
|
PMID: 22497443 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Young infants with influenza virus infection are frequently hospitalized, and are at risk of serious complications including death. With the emergence of pandemic influenza A/H1N1 2009, oseltamivir was approved for use in Europe and the USA, including use in infants aged < 3 months. However, few data are available regarding the safety of oseltamivir treatment for influenza in infants aged < 3 months. Methods: The clinical data from Japanese infants aged < 3 months with laboratory-confirmed influenza virus infections, who were treated with oseltamivir between October 2009 and April 2011, were collected and analyzed. Results: Forty-four infants were included in the study. The median age was 1 month (range 4 days to 2 months) and median body weight was 4.5 kg (range 2.6-7.6 kg). Thirty-eight infants (86%) had no underlying diseases. The most common presenting symptom was fever (42 infants, 95%). There were no cases of influenza-associated encephalopathy or myocarditis. The median time between the onset of influenza symptoms and initiation of oseltamivir treatment was 0 days (range 0-7 days), with treatment initiated within 1 day in 40 infants (91%). The oseltamivir dose was 1.5-2 mg/kg twice daily in 98% of infants. No serious adverse events were identified during treatment. All infants recovered completely. Conclusions: Treatment of influenza with oseltamivir 1.5-2 mg/kg twice daily may be safe in infants aged < 3 months. |
| | |
Authors:
|
Ichiro Morioka; Shigeaki Nonoyama; Keiko Tanaka-Taya; Toshiaki Ihara; Norio Sugaya; Ikuya Ueta; Takuji Kumagai; Kenji Okada; Mitsuaki Hosoya; Nobuhiko Okabe; Tsuneo Morishima |
Related Documents
:
|
22406873 - Evaluation of viral load in infants hospitalized with bronchiolitis caused by respirato... 3627563 - At least one thalamotelencephalic pathway in cartilaginous fishes projects to the media... 15460303 - Diet counseling during the infant oral health visit. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-12 |
Journal Detail:
|
Title: Scandinavian journal of infectious diseases Volume: - ISSN: 1651-1980 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0215333 Medline TA: Scand J Infect Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pediatrics, Kobe University Graduate School of Medicine , Kobe. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Climate Change and the Cost of Conserving Species in Madagascar.
Next Document: Discovery and characterization of an inhibitor of glucosylceramide synthase.