Document Detail

Survey of Bacteroides fragilis group susceptibility patterns in Canada.
MedLine Citation:
PMID:  1605600     Owner:  NLM     Status:  MEDLINE    
The in vitro activities of penicillin, clindamycin, chloramphenicol, metronidazole, piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin-sulbactam, cefoxitin, ceftizoxime, cefotetan, moxalactam, and imipenem against 348 Bacteroides fragilis group isolates collected from six Canadian cities during 1990 were determined by the National Committee for Clinical Laboratory Standards (NCCLS) agar dilution technique. All isolates were susceptible to chloramphenicol, metronidazole, piperacillin-tazobactam, and imipenem. For the other antibiotics tested, the following resistance rates were observed: penicillin, 97%; clindamycin, 9%; piperacillin, 19%; ticarcillin, 31%; ticarcillin-clavulanate, 0.28%; ampicillin-sulbactam, 0.85%; cefoxitin, 26%; ceftizoxime, 15%; cefotetan, 53%; and moxalactam, 17%. Susceptibility profiles to beta-lactam antibiotics varied among the different species tested: B. fragilis and Bacteroides vulgatus demonstrated lower resistance rates than Bacteroides distasonis and indole-positive Bacteroides thetaiotaomicron and Bacteroides ovatus. Ceftizoxime results should be interpreted cautiously, because the MICs obtained with the recommended NCCLS control strain were lower than expected.
A M Bourgault; F Lamothe; D J Hoban; M T Dalton; P C Kibsey; G Harding; J A Smith; D E Low; H Gilbert
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  36     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-07-14     Completed Date:  1992-07-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  IM    
Hôpital Saint-Luc, Montréal, Québec, Canada.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Bacteroides Infections / epidemiology,  microbiology
Bacteroides fragilis / drug effects*,  enzymology
Drug Resistance, Microbial
Microbial Sensitivity Tests
beta-Lactamases / metabolism
Reg. No./Substance:
0/Anti-Bacterial Agents; EC

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