Document Detail

Survey of Amanita phalloides poisoning: clinical findings and follow-up evaluation.
MedLine Citation:
PMID:  18375639     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to evaluate the severity of hepatic and kidney damage with a focus on their reversibility, and to analyze the prognostic factors following Amanita phalloides poisoning based on calls made to the Czech Toxicological Information Centre. A variety of clinical and laboratory parameters were collected. Student's t-test and Fisher's test were used for statistical analysis. Amanita phalloides poisoning was verified in 34 cases (5 children, 29 adults). The following findings emerged: vomiting (76%), diarrhea (62%), hepatic failure (24%), and renal failure (11%). Two patients died on the fifth day after mushroom ingestion. In 18 patients, all serum levels normalized by the time of discharge; in 10 patients up to 7.3 months on average after discharge. Five patients did not comply with follow-up. Renal damage persisted in only one patient, 19 months after discharge. In conclusion, the interval to recovery from hepatic and renal damage by the time of discharge depended on a decrease in the prothrombin index and an increase in serum transaminase and bilirubin levels. Recovery was favorable in all subjects who survived the acute phase of poisoning, except in one patient with a solitary kidney.
M Krenová; D Pelclová; T Navrátil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  26     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  955-61     Citation Subset:  IM    
Department of Occupational Medicine, Toxicological Information Centre, Charles University, General University Hospital, Prague, Czech Republic.
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MeSH Terms
Child, Preschool
Combined Modality Therapy
Follow-Up Studies
Kidney Failure, Acute / chemically induced,  diagnosis,  physiopathology
Liver Failure, Acute / chemically induced,  diagnosis,  physiopathology
Liver Function Tests
Middle Aged
Mushroom Poisoning / diagnosis*,  physiopathology,  therapy
Plants, Toxic / poisoning*
Poison Control Centers
Prothrombin Time
Recovery of Function
Retrospective Studies

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