| Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa. | |
MedLine Citation:
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PMID: 19935449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants. |
Authors:
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Gert U van Zyl; Mark F Cotton; Mathilda Claassen; Charmaine Abrahams; Wolfgang Preiser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 29 ISSN: 1532-0987 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-31 Completed Date: 2010-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: United States |
Other Details:
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Languages: eng Pagination: 370-1 Citation Subset: IM |
Affiliation:
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Division of Medical Virology, Stellenbosch University, Tygerberg, South Africa. guvz@sun.ac.za. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
/
pharmacology* Drug Resistance, Viral / genetics* HIV Infections* / drug therapy, epidemiology, transmission, virology HIV-1 / drug effects*, enzymology, genetics Humans Infant Mutation* Population Surveillance / methods Prevalence Reverse Transcriptase Inhibitors / pharmacology* South Africa / epidemiology World Health Organization |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Reverse Transcriptase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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