Document Detail


Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa.
MedLine Citation:
PMID:  19935449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants.
Authors:
Gert U van Zyl; Mark F Cotton; Mathilda Claassen; Charmaine Abrahams; Wolfgang Preiser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  29     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-31     Completed Date:  2010-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  370-1     Citation Subset:  IM    
Affiliation:
Division of Medical Virology, Stellenbosch University, Tygerberg, South Africa. guvz@sun.ac.za.
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MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / pharmacology*
Drug Resistance, Viral / genetics*
HIV Infections* / drug therapy,  epidemiology,  transmission,  virology
HIV-1 / drug effects*,  enzymology,  genetics
Humans
Infant
Mutation*
Population Surveillance / methods
Prevalence
Reverse Transcriptase Inhibitors / pharmacology*
South Africa / epidemiology
World Health Organization
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Reverse Transcriptase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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