Document Detail


Surveillance of stage I testicular seminoma: British Columbia Cancer Agency Experience 1992 to 2002.
MedLine Citation:
PMID:  16527585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To review the changes in the use of surveillance in Stage I seminoma in British Columbia during the past decade and to compare the relapse rates provincially against those in published reports. Postorchiectomy surveillance of Stage I seminoma is an alternative to adjuvant radiotherapy. The relapse rate from a pooled surveillance series was 18% at 5 years. METHODS: We reviewed the British Columbia Cancer Agency Tumour Registry records for all cases registered with a diagnosis of seminoma of the testes referred to the BCCA between 1992 and 2002. Patients not treated with radiotherapy within 4 months of referral were reviewed for patient and disease parameters (age, rete testes invasion, size, lymphatic invasion), relapse, salvage treatment, and survival. RESULTS: A total of 458 patients with Stage I seminoma were identified. Of these, 93 went onto surveillance. The annual percentage of patients going onto surveillance increased from 10% in 1992 to 33% by 2002. The median follow-up was 33 months. The 5-year actuarial relapse-free survival rate was 78%. Relapse was more common in those with known adverse prognostic factors (rete invasion or size greater than 4 cm). The actuarial 5-year relapse free rate was 86%, 71%, and 50% for patients with no risk factor, one risk factor, or both risk factors, respectively. The disease-specific survival rate at 5 years was 96%. CONCLUSIONS: Surveillance of patients with seminoma in British Columbia increased between 1992 and 2002. The relapse and survival rates in this population-based series were similar to those previously reported.
Authors:
Scott Tyldesley; David Voduc; Michael McKenzie; Graeme Duncan; Mitchell Liu; Douglas Wu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urology     Volume:  67     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-10     Completed Date:  2006-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  594-8     Citation Subset:  IM    
Affiliation:
Radiation Therapy Program, British Columbia Cancer Agency, Vancouver Cancer Centre, Vancouver, British Columbia, Canada. styldesl@bccancer.bc.ca
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
British Columbia
Disease-Free Survival
Humans
Male
Middle Aged
Neoplasm Recurrence, Local / epidemiology*
Neoplasm Staging
Population Surveillance*
Seminoma / epidemiology*,  pathology,  therapy*
Survival Rate
Testicular Neoplasms / epidemiology*,  pathology,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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