Document Detail

Surveillance of extreme hyperbilirubinaemia in Denmark. A method to identify the newborn infants.
MedLine Citation:
PMID:  18482165     Owner:  NLM     Status:  MEDLINE    
AIM: To describe the incidence of infants born at term or near-term with extreme hyperbilirubinaemia. METHODS: The study period was between 1 January 2002 and 31 December 2005, and included all infants born alive at term or near-term in Denmark. Medical reports on all newborn infants with a total serum bilirubin concentration (TSB) > or = 450 micromol/L were obtained by linking laboratory data to the unique Danish personal identification number. RESULTS: In total, 113 infants were included, that is, an incidence of 45/100,000 live births. Thirty-seven infants presented in hospital, 2 after home birth and the others after having been discharged. The maximum TSB was 485 (450-734) micromol/L (median [range]) and appeared latest amongst those infants admitted from home, but was not different from the maximum TSB of the nondischarged infants. Forty-three infants had symptoms of early-phase acute bilirubin encephalopathy; one infant had advanced-phase symptoms. Four infants received an exchange transfusion. ABO blood group incompatibility was present in 52 infants. Thirty-seven infants were of non-Caucasian descent. CONCLUSION: A method to obtain the national epidemiological data is presented. The observed incidence of extreme hyperbilirubinaemia is higher than previously reported in Denmark. This is mainly due to a very sensitive method of identifying the study group.
Jesper Vandborg Bjerre; Jes Reinholdt Petersen; Finn Ebbesen
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Publication Detail:
Type:  Journal Article     Date:  2008-05-14
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  97     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1030-4     Citation Subset:  IM    
Department of Paediatrics, University Hospital Skejby, Aarhus, Denmark.
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MeSH Terms
Coombs' Test
Denmark / epidemiology
Gestational Age
Hyperbilirubinemia / diagnosis,  epidemiology*,  physiopathology*
Infant, Newborn
Mass Screening / methods*
Population Surveillance / methods*
Severity of Illness Index
Comment In:
Acta Paediatr. 2008 Aug;97(8):1002-3   [PMID:  18540903 ]

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