Document Detail

Surveillance for endometrial cancer in women on tamoxifen: the role of liquid-based endometrial cytology - cytohistological correlation in a population of 168 women.
MedLine Citation:
PMID:  18196906     Owner:  NLM     Status:  MEDLINE    
AIMS: The aim of this study was to evaluate the utility of liquid-based cytology for endometrial surveillance in patients receiving tamoxifen.
METHODS: One hundred and sixty-eight women scheduled for hysteroscopy were enrolled in the study. The women sequentially underwent hysteroscopy, endometrial cytology and biopsy.
RESULTS: Endometrial biopsy only was inadequate in 112 (67%) patients, both endometrial biopsy and cytology were inadequate in 19 (11%) patients, endometrial cytology only was inadequate in 4 (2%) patients, and both endometrial biopsy and cytology were adequate in 33 (20%) patients. Overall, endometrial biopsy was inadequate in 131 (78%) patients and endometrial cytology in 23 (14%) patients. Endometrial cytology provided sufficient material for diagnosis more often than endometrial biopsy (p < 0.05). In the series of 33 patients (20%) in whom both endometrial cytology and biopsy were adequate, there was a 100% correlation between the endometrial cytology and biopsy results.
CONCLUSIONS: For the first time, this study shows the diagnostic efficacy of liquid-based endometrial cytology in the follow-up of women receiving tamoxifen. It could be applied solely or in conjunction with ultrasonography.
Anna Maria Buccoliero; Massimiliano Fambrini; Chiara Francesca Gheri; Francesca Castiglione; Francesca Garbini; Alfredo Barbetti; Duccio Rossi Degl'Innocenti; Daniela Moncini; Antonio Taddei; Gianni Bargelli; Gianfranco Scarselli; Mauro Marchionni; Gian Luigi Taddei
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-01-14
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  65     ISSN:  1423-002X     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-05     Completed Date:  2008-07-22     Revised Date:  2012-01-04    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  240-6     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel
Department of Human Pathology and Oncology, University of Florence, Florence, Italy.
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MeSH Terms
Aged, 80 and over
Antineoplastic Agents, Hormonal / adverse effects*
Breast Neoplasms / drug therapy
Carcinoma, Endometrioid / chemically induced*,  pathology
Endometrial Neoplasms / chemically induced*,  pathology
Endometrium / pathology*
Middle Aged
Tamoxifen / adverse effects*
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 10540-29-1/Tamoxifen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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