Document Detail


Surveillance of Pseudomonas aeruginosa-isolates in a neonatal intensive care unit over a one year-period.
MedLine Citation:
PMID:  15330394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Outbreaks of gram-negative bacteria such as Pseudomonas aeruginosa in neonatal intensive care units (NICU) can be life-threatening to pre-term infants, which are highly susceptible to serious infections with bacteria. Forty-two ventilated neonates in the NICU of the University Children's Hospital of Tuebingen were found to be colonized (n = 40) or infected (n = 2) with P. aeruginosa within a sampling period of one year. To investigate the colonization patterns and identify potential outbreak sources, epidemiological investigations, environmental surveillance and typing by serotyping and pulsed-field gel electrophoresis of the recovered isolates were performed. The investigation demonstrated a genetically related cluster of P. aeruginosa isolates during the surveillance period in 39 neonates and a second cluster at the end of the period in two neonates. A third strain representing a genetically distinct group was found in only one patient. Environmental investigations demonstrated the presence of P. aeruginosa in the ventilation equipment of 22 patients: binasal prongs (n = 22), water reservoir (n = 9), and heater (n = 1). In one case, P. aeruginosa was found in breast milk. Other environmental investigations revealed no P. aeruginosa. Although no evidence for a unique source was found, a series of intervention steps were initiated by the NICU personnel, medical microbiologists and infection control experts. The intervention steps included reinforced training of health care staff and a change from chemical to thermal disinfection of binasal prongs. Implementation of these measurements successfully stopped the recurrent occurrence of P. aeruginosa colonization.
Authors:
Lutz Thomas Zabel; Peter Heeg; Rangmar Goelz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of hygiene and environmental health     Volume:  207     ISSN:  1438-4639     ISO Abbreviation:  Int J Hyg Environ Health     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-08-27     Completed Date:  2004-10-26     Revised Date:  2007-06-21    
Medline Journal Info:
Nlm Unique ID:  100898843     Medline TA:  Int J Hyg Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
Affiliation:
Dep. of Laboratory Medicine, Klinik am Eichert, Göppingen, Germany. lutz.zabel@kae.de
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MeSH Terms
Descriptor/Qualifier:
Cross Infection / etiology*,  prevention & control*
DNA, Bacterial / analysis
Disease Outbreaks*
Disinfection
Epidemiologic Studies
Germany
Hospitals, University / statistics & numerical data
Humans
Infant, Newborn
Infant, Premature
Infection Control
Intensive Care Units, Neonatal / statistics & numerical data*
Population Surveillance
Pseudomonas Infections / etiology*,  prevention & control*
Pseudomonas aeruginosa / classification*,  genetics,  isolation & purification*
Risk Factors
Serotyping
Chemical
Reg. No./Substance:
0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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